Down‐regulation of an established immune response via chemical carcinogen or UVB‐altered skin
The ability to produce antigen‐specific down‐regulation of an established immune response was investigated in 2,4,6‐trinitrochlorobenzene (TNCB)‐immune mice by delivery of antigen through chemical carcinogen‐ or ultraviolet B (UVB)‐treated skin. When TNCB‐immune mice were treated on the dorsal trunk...
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| Veröffentlicht in: | Immunology and cell biology 1997-06, Vol.75 (3), p.238-244 |
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| creator | Chen, Yi‐Peng Woods, Gregory M Dandie, Geoffrey W Muller, H Konrad |
| description | The ability to produce antigen‐specific down‐regulation of an established immune response was investigated in 2,4,6‐trinitrochlorobenzene (TNCB)‐immune mice by delivery of antigen through chemical carcinogen‐ or ultraviolet B (UVB)‐treated skin. When TNCB‐immune mice were treated on the dorsal trunk skin with 7,12‐dimethylbenz(a)anthracene (DMBA) followed by TNCB there was an antigen‐specific reduction in both contact sensitivity and antibody production. Further, immune mice that received spleen cells from naive syngeneic donors treated with DMBA followed by TNCB also exhibited a reduction in both contact sensitivity and antibody production. In contrast, mice treated with UVB irradiation followed by TNCB had a reduction in contact sensitivity but not antibody production. These results provide evidence that an ongoing immune response can be manipulated by immunization through a modified skin immune system. This may provide a beneficial approach for the treatment of autoimmune disease. |
| doi_str_mv | 10.1038/icb.1997.37 |
| format | Article |
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When TNCB‐immune mice were treated on the dorsal trunk skin with 7,12‐dimethylbenz(a)anthracene (DMBA) followed by TNCB there was an antigen‐specific reduction in both contact sensitivity and antibody production. Further, immune mice that received spleen cells from naive syngeneic donors treated with DMBA followed by TNCB also exhibited a reduction in both contact sensitivity and antibody production. In contrast, mice treated with UVB irradiation followed by TNCB had a reduction in contact sensitivity but not antibody production. These results provide evidence that an ongoing immune response can be manipulated by immunization through a modified skin immune system. This may provide a beneficial approach for the treatment of autoimmune disease.</description><identifier>ISSN: 0818-9641</identifier><identifier>EISSN: 1440-1711</identifier><identifier>DOI: 10.1038/icb.1997.37</identifier><identifier>PMID: 9243288</identifier><language>eng</language><publisher>United States: Nature Publishing Group</publisher><subject>9,10-Dimethyl-1,2-benzanthracene - administration & dosage ; 9,10-Dimethyl-1,2-benzanthracene - immunology ; Animals ; Antibody Formation ; antibody production ; Antigens - administration & dosage ; contact sensitivity ; Dermatitis, Contact - etiology ; Dermatitis, Contact - therapy ; Down-Regulation ; Female ; Immunization ; Immunosuppression ; Langerhans cells ; Langerhans Cells - drug effects ; Langerhans Cells - immunology ; Langerhans Cells - radiation effects ; Male ; Mice ; Mice, Inbred BALB C ; Picryl Chloride - administration & dosage ; Picryl Chloride - immunology ; Skin - drug effects ; Skin - immunology ; Skin - radiation effects ; Ultraviolet Rays</subject><ispartof>Immunology and cell biology, 1997-06, Vol.75 (3), p.238-244</ispartof><rights>1997 Australasian Society for Immunology Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3597-e0082df77a41403b3f4ccadc7ae1a7f8a3ec6ca5be992d9dd617fcad124f92743</citedby><cites>FETCH-LOGICAL-c3597-e0082df77a41403b3f4ccadc7ae1a7f8a3ec6ca5be992d9dd617fcad124f92743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1038%2Ficb.1997.37$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1038%2Ficb.1997.37$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9243288$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Yi‐Peng</creatorcontrib><creatorcontrib>Woods, Gregory M</creatorcontrib><creatorcontrib>Dandie, Geoffrey W</creatorcontrib><creatorcontrib>Muller, H Konrad</creatorcontrib><title>Down‐regulation of an established immune response via chemical carcinogen or UVB‐altered skin</title><title>Immunology and cell biology</title><addtitle>Immunol Cell Biol</addtitle><description>The ability to produce antigen‐specific down‐regulation of an established immune response was investigated in 2,4,6‐trinitrochlorobenzene (TNCB)‐immune mice by delivery of antigen through chemical carcinogen‐ or ultraviolet B (UVB)‐treated skin. When TNCB‐immune mice were treated on the dorsal trunk skin with 7,12‐dimethylbenz(a)anthracene (DMBA) followed by TNCB there was an antigen‐specific reduction in both contact sensitivity and antibody production. Further, immune mice that received spleen cells from naive syngeneic donors treated with DMBA followed by TNCB also exhibited a reduction in both contact sensitivity and antibody production. In contrast, mice treated with UVB irradiation followed by TNCB had a reduction in contact sensitivity but not antibody production. These results provide evidence that an ongoing immune response can be manipulated by immunization through a modified skin immune system. This may provide a beneficial approach for the treatment of autoimmune disease.</description><subject>9,10-Dimethyl-1,2-benzanthracene - administration & dosage</subject><subject>9,10-Dimethyl-1,2-benzanthracene - immunology</subject><subject>Animals</subject><subject>Antibody Formation</subject><subject>antibody production</subject><subject>Antigens - administration & dosage</subject><subject>contact sensitivity</subject><subject>Dermatitis, Contact - etiology</subject><subject>Dermatitis, Contact - therapy</subject><subject>Down-Regulation</subject><subject>Female</subject><subject>Immunization</subject><subject>Immunosuppression</subject><subject>Langerhans cells</subject><subject>Langerhans Cells - drug effects</subject><subject>Langerhans Cells - immunology</subject><subject>Langerhans Cells - radiation effects</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Picryl Chloride - administration & dosage</subject><subject>Picryl Chloride - immunology</subject><subject>Skin - drug effects</subject><subject>Skin - immunology</subject><subject>Skin - radiation effects</subject><subject>Ultraviolet Rays</subject><issn>0818-9641</issn><issn>1440-1711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kLtOAzEQRS0ECiFQUSO5okEb7LUTr0sIr0hBNITWmvXOBsM-gp0F0fEJfCNfgqNElFQz0px7NLqEHHM25Exk587mQ661Ggq1Q_pcSpZwxfku6bOMZ4keS75PDkJ4YYypNBM90tOpFGmW9QlctR_Nz9e3x0VXwcq1DW1LCg3FsIK8cuEZC-rqumuQegzLtglI3x1Q-4y1s1BRC966pl1gTHo6f7qMNqhW6GMwvLrmkOyVUAU82s4Bmd9cP07uktnD7XRyMUusGGmVIGNZWpRKgeSSiVyU0loorALkoMoMBNqxhVGOWqeFLooxV2UEeCpLnSopBuR041369q2L75vaBYtVBQ22XTB8zJQQIxXBsw1ofRuCx9IsvavBfxrOzLpQEws160KNWNMnW22X11j8sdsG411s7h-uws__VGZ6P7lc79H6C6nvhI8</recordid><startdate>199706</startdate><enddate>199706</enddate><creator>Chen, Yi‐Peng</creator><creator>Woods, Gregory M</creator><creator>Dandie, Geoffrey W</creator><creator>Muller, H Konrad</creator><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope></search><sort><creationdate>199706</creationdate><title>Down‐regulation of an established immune response via chemical carcinogen or UVB‐altered skin</title><author>Chen, Yi‐Peng ; Woods, Gregory M ; Dandie, Geoffrey W ; Muller, H Konrad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3597-e0082df77a41403b3f4ccadc7ae1a7f8a3ec6ca5be992d9dd617fcad124f92743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>9,10-Dimethyl-1,2-benzanthracene - administration & dosage</topic><topic>9,10-Dimethyl-1,2-benzanthracene - immunology</topic><topic>Animals</topic><topic>Antibody Formation</topic><topic>antibody production</topic><topic>Antigens - administration & dosage</topic><topic>contact sensitivity</topic><topic>Dermatitis, Contact - etiology</topic><topic>Dermatitis, Contact - therapy</topic><topic>Down-Regulation</topic><topic>Female</topic><topic>Immunization</topic><topic>Immunosuppression</topic><topic>Langerhans cells</topic><topic>Langerhans Cells - drug effects</topic><topic>Langerhans Cells - immunology</topic><topic>Langerhans Cells - radiation effects</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Picryl Chloride - administration & dosage</topic><topic>Picryl Chloride - immunology</topic><topic>Skin - drug effects</topic><topic>Skin - immunology</topic><topic>Skin - radiation effects</topic><topic>Ultraviolet Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Yi‐Peng</creatorcontrib><creatorcontrib>Woods, Gregory M</creatorcontrib><creatorcontrib>Dandie, Geoffrey W</creatorcontrib><creatorcontrib>Muller, H Konrad</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Immunology and cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Yi‐Peng</au><au>Woods, Gregory M</au><au>Dandie, Geoffrey W</au><au>Muller, H Konrad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Down‐regulation of an established immune response via chemical carcinogen or UVB‐altered skin</atitle><jtitle>Immunology and cell biology</jtitle><addtitle>Immunol Cell Biol</addtitle><date>1997-06</date><risdate>1997</risdate><volume>75</volume><issue>3</issue><spage>238</spage><epage>244</epage><pages>238-244</pages><issn>0818-9641</issn><eissn>1440-1711</eissn><abstract>The ability to produce antigen‐specific down‐regulation of an established immune response was investigated in 2,4,6‐trinitrochlorobenzene (TNCB)‐immune mice by delivery of antigen through chemical carcinogen‐ or ultraviolet B (UVB)‐treated skin. When TNCB‐immune mice were treated on the dorsal trunk skin with 7,12‐dimethylbenz(a)anthracene (DMBA) followed by TNCB there was an antigen‐specific reduction in both contact sensitivity and antibody production. Further, immune mice that received spleen cells from naive syngeneic donors treated with DMBA followed by TNCB also exhibited a reduction in both contact sensitivity and antibody production. In contrast, mice treated with UVB irradiation followed by TNCB had a reduction in contact sensitivity but not antibody production. These results provide evidence that an ongoing immune response can be manipulated by immunization through a modified skin immune system. This may provide a beneficial approach for the treatment of autoimmune disease.</abstract><cop>United States</cop><pub>Nature Publishing Group</pub><pmid>9243288</pmid><doi>10.1038/icb.1997.37</doi><tpages>8</tpages></addata></record> |
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| subjects | 9,10-Dimethyl-1,2-benzanthracene - administration & dosage 9,10-Dimethyl-1,2-benzanthracene - immunology Animals Antibody Formation antibody production Antigens - administration & dosage contact sensitivity Dermatitis, Contact - etiology Dermatitis, Contact - therapy Down-Regulation Female Immunization Immunosuppression Langerhans cells Langerhans Cells - drug effects Langerhans Cells - immunology Langerhans Cells - radiation effects Male Mice Mice, Inbred BALB C Picryl Chloride - administration & dosage Picryl Chloride - immunology Skin - drug effects Skin - immunology Skin - radiation effects Ultraviolet Rays |
| title | Down‐regulation of an established immune response via chemical carcinogen or UVB‐altered skin |
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