Insect venom immunotherapy induces interleukin‐10 production and a Th2‐to‐Th1 shift, and changes surface marker expression in venom‐allergic subjects

The current study was carried out to elucidate the immunoregulatory changes induced by venom immunotherapy (VIT) in bee or wasp allergic subjects. All subjects included in this study had a history of severe systemic allergic reactions to stings of the respective insect as well as positive skin tests...

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Veröffentlicht in:	European journal of immunology 1997-05, Vol.27 (5), p.1131-1139
Hauptverfasser:	Bellinghausen, Iris, Metz, Gudrun, Enk, Alexander H., Christmann, Steffen, Knop, JÜRgen, Saloga, Joachim
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergens - pharmacology Allergens - therapeutic use Allergy Antibodies, Monoclonal - pharmacology Antigens, CD - biosynthesis Antigens, Surface - biosynthesis Bee Venoms - immunology Bee Venoms - pharmacology Bee Venoms - therapeutic use CD40 Antigens - biosynthesis CD40 Ligand Cytokine Desensitization, Immunologic - methods Down-Regulation - immunology Humans Hymenoptera Immunotherapy Insect Bites and Stings - immunology Insect Bites and Stings - therapy Insect venom Interferon-gamma - biosynthesis Interferon-gamma - immunology Interleukin-10 - biosynthesis Interleukin-10 - genetics Interleukin-4 - biosynthesis Interleukin-4 - immunology Interleukin‐10 Ligands Lymphocyte Activation - drug effects Lymphocyte Count Membrane Glycoproteins - biosynthesis Receptors, IgE - biosynthesis Receptors, Interleukin - biosynthesis Receptors, Interleukin-4 RNA, Messenger - biosynthesis T-Lymphocyte Subsets - cytology Th1 Cells - drug effects Th1 Cells - immunology Th2 Cells - drug effects Th2 Cells - immunology Time Factors Wasp Venoms - immunology Wasp Venoms - pharmacology Wasp Venoms - therapeutic use
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