Evaluation of manual and image analysis quantification of DNA damage in the alkaline comet assay

The alkaline comet assay or single cell microgel electrophoresis assay is a sensitive method of detecting DNA strand breaks and alkali labile sites in individual cells. The results of this assay can be analysed by different methods. In this study we compared analyses of the same slides by a manual m...

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Veröffentlicht in:	Mutagenesis 1997-07, Vol.12 (4), p.209-214
Hauptverfasser:	McCarthy, P.J., Sweetman, S.F., McKenna, P.G., McKelvey-Martin, V.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Chemical mutagenesis DNA - analysis DNA - chemistry DNA Damage - drug effects Dose-Response Relationship, Drug Electrophoresis, Agar Gel - methods Hydrogen Peroxide - pharmacology Image Processing, Computer-Assisted - methods Leukemia, Erythroblastic, Acute - drug therapy Leukemia, Erythroblastic, Acute - genetics Medical sciences Mice Mutagenicity Tests Oxidants - pharmacology Reproducibility of Results Toxicology Tumor Cells, Cultured
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