Industrial Genotoxicology Group collaborative trial to investigate cell cycle parameters in human lymphocyte cytogenetics studies

Human lymphocyte cultures have been used for many years for assessing the in vitro clastogenic potential of test substances. In these assays the harvest time should be based on the cell cycle time in order to ensure that cells are sampled at an appropriate time for the detection of clastogenic effec...

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Veröffentlicht in:	Mutagenesis 1997-05, Vol.12 (3), p.163-167
Hauptverfasser:	Henderson, L., Jones, E., Brooks, T., Chételat, A., Chiliutti, P., Freemantle, M., Howard, C.A., Mackay, J., Phillips, B., Riley, S., Roberts, C., Wotton, A.K., van de Waart, E.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bromodeoxyuridine - metabolism Cell Cycle Cells, Cultured Chemical mutagenesis Chromosome Aberrations Cytogenetics - methods Evaluation Studies as Topic Humans In Vitro Techniques Laboratories Lymphocytes - cytology Lymphocytes - drug effects Lymphocytes - metabolism Medical sciences Microsomes, Liver - metabolism Mutagenicity Tests - methods Mutagens - metabolism Mutagens - toxicity Polyploidy Rats Time Factors Toxicology
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