Detection of DNA lesions induced by chemical mutagens using the single-cell gel electrophoresis (Comet) assay.: 2. Relationship between DNA migration and alkaline condition

The alkaline condition is an important factor for the alkaline single-cell gel electrophoresis (SCG) assay to detect the genotoxic effects of chemicals. In order to understand the relationship between DNA migration and alkaline condition, the effect of 13 model chemical mutagens with different modes...

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Veröffentlicht in:	Mutation research 1997-09, Vol.393 (1), p.107-113
Hauptverfasser:	Miyamae, Youichi, Iwasaki, Kouichi, Kinae, Naohide, Tsuda, Shuji, Murakami, Michiko, Tanaka, Makiko, Sasaki, Yu F
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline single cell gel electrophoresis (SCG) assay Alkylating Agents - toxicity Animals Chemical mutagen CHO Cells Comet assay Cricetinae Cross-Linking Reagents - toxicity DNA - drug effects DNA - genetics DNA - isolation & purification DNA Damage DNA lesion Electrophoresis - methods Evaluation Studies as Topic Hydrogen-Ion Concentration Mutagenicity Tests - methods Mutagens - toxicity
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