Cordycepin analogs of 2',5'-oligoadenylate inhibit human immunodeficiency virus infection via inhibition of reverse transcriptase

Analogues of 2',5'-oligoadenylates (2-5A), the cordycepin (3'-deoxyadenosine) core trimer (Co3) and its 5'-monophosphate derivative (pCo3), were shown to display pronounced anti-human immunodeficiency virus type 1 (HIV-1) activity in vitro. Treatment of HIV-1 infected H9 cells wi...

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Veröffentlicht in:	Biochemistry (Easton) 1991-02, Vol.30 (8), p.2027-2033
Hauptverfasser:	Mueller, Werner E. G, Weiler, Barbara E, Charubala, Ramamurthy, Pfleiderer, Wolfgang, Leserman, Lee, Sobol, Robert W, Suhadolnik, Robert J, Schroeder, Heinz C
Format:	Artikel
Sprache:	eng
Schlagworte:	Action of physical and chemical agents Adenine Nucleotides - pharmacology Antiviral Agents - pharmacology Biological and medical sciences Cell Line Deoxyadenosines - pharmacology Fundamental and applied biological sciences. Psychology HIV-1 - drug effects HIV-1 - enzymology HIV-1 - physiology Humans Liposomes Microbiology Nucleic Acid Synthesis Inhibitors Oligoribonucleotides - pharmacology Reverse Transcriptase Inhibitors RNA, Ribosomal - metabolism RNA, Transfer, Lys - isolation & purification RNA, Transfer, Lys - metabolism Structure-Activity Relationship Virology Virus Replication - drug effects
Online-Zugang:	Volltext
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