Phase I study of immunotherapy of cutaneous metastases of human carcinoma using allogeneic and xenogeneic MHC DNA-liposome complexes

The generation of strong tumor-specific immunity by in situ gene therapy is an attractive approach for the eradication of human cancer lesions. The objectives of this study were to examine the toxicities of employing the human HLA-A2, HLA-B13 and the murine H-2K genes to generate tumor regression in...

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Veröffentlicht in:	Gene therapy 1997-08, Vol.4 (8), p.783-790
Hauptverfasser:	HUI, K. M, ANG, P. T, HUANG, L, TAY, S. K
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biotechnology Breast Neoplasms - immunology Breast Neoplasms - therapy Cancer Carcinoma, Non-Small-Cell Lung - immunology Carcinoma, Non-Small-Cell Lung - therapy Cervical cancer Cervix Clinical trials Deoxyribonucleic acid DNA Female Fundamental and applied biological sciences. Psychology Gene therapy Gene Transfer Techniques Genes, MHC Class I Genetic Therapy - methods Health. Pharmaceutical industry Histocompatibility antigen H-2 Histocompatibility antigen HLA Humans Immunotherapy Immunotherapy - methods Industrial applications and implications. Economical aspects Liposomes Lung Neoplasms - immunology Lung Neoplasms - therapy Major histocompatibility complex Melanoma - immunology Melanoma - therapy Metastases Nodules Ovarian cancer Ovarian carcinoma Ovarian Neoplasms - immunology Ovarian Neoplasms - therapy Ovaries Patients Skin Neoplasms - immunology Skin Neoplasms - secondary Skin Neoplasms - therapy Tumors Uterine Cervical Neoplasms - immunology Uterine Cervical Neoplasms - therapy
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