The CD19 complex of B lymphocytes. Activation of phospholipase C by a protein tyrosine kinase-dependent pathway that can be enhanced by the membrane IgM complex

We have investigated the mechanism by which the membrane protein complex of the B lymphocyte that contains CD19 and CR2 activates phospholipase C (PLC) to induce a rise in [CA2+]i. The CD19 complex resembled the membrane IgM complex in that three protein tyrosine kinase inhibitors suppressed increas...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of immunology (1950) 1991-12, Vol.147 (11), p.3663-3671
Hauptverfasser:	Carter, RH, Tuveson, DA, Park, DJ, Rhee, SG, Fearon, DT
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - physiology Antigens, CD19 Antigens, Differentiation, B-Lymphocyte - physiology B-Lymphocytes - physiology Biological and medical sciences Calcium - physiology Enzyme Activation Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Immunoglobulin M - physiology In Vitro Techniques Inositol Phosphates - metabolism Lymphocyte Activation Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation Macromolecular Substances Molecular Weight Phorbol Esters - pharmacology Phosphoproteins - chemistry Phosphoproteins - metabolism Phosphotyrosine Protein-Tyrosine Kinases - physiology Receptor Aggregation Receptors, Antigen, B-Cell - physiology Receptors, Complement - physiology Receptors, Complement 3d Signal Transduction Type C Phospholipases - physiology Tyrosine - analogs & derivatives Tyrosine - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!