Toxic activity of mimics of the host-specific pathotoxin PM-toxin on corn carrying Texas male-sterile cytoplasm
To investigate the structure-activity relationships of host-specific HMT- and PM-toxins, 8 mimics of PM-toxin A, a component of the host-specific corn pathotoxin produced by Phyllosticta maydis, were synthesized as stereoisomeric mixtures. All the mimics, except for PM-7137, had four β-ketol groups...
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| Veröffentlicht in: | Agricultural and biological chemistry 1991-04, Vol.55 (4), p.1061-1070 |
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| container_title | Agricultural and biological chemistry |
| container_volume | 55 |
| creator | Suzuki, Y. (Institute of Physical and Chemical Research, Wako, Saitama (Japan)) Kono, Y Takahashi, Y Suenaga, K Daly, J.M Knoche, H.W Sakurai, A |
| description | To investigate the structure-activity relationships of host-specific HMT- and PM-toxins, 8 mimics of PM-toxin A, a component of the host-specific corn pathotoxin produced by Phyllosticta maydis, were synthesized as stereoisomeric mixtures. All the mimics, except for PM-7137, had four β-ketol groups spaced by tri- and tetra-methylenes, which is shorter than the penta-methylenes involved in native PM-toxins. A comparison of their biological activity clearly demonstrated the general structural features necessary for potent activity: four β-ketol groups were necessary with a spacing of chains equal to or longer than penta-methylene. |
| doi_str_mv | 10.1080/00021369.1991.10870691 |
| format | Article |
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(Institute of Physical and Chemical Research, Wako, Saitama (Japan)) ; Kono, Y ; Takahashi, Y ; Suenaga, K ; Daly, J.M ; Knoche, H.W ; Sakurai, A</creator><creatorcontrib>Suzuki, Y. (Institute of Physical and Chemical Research, Wako, Saitama (Japan)) ; Kono, Y ; Takahashi, Y ; Suenaga, K ; Daly, J.M ; Knoche, H.W ; Sakurai, A</creatorcontrib><description>To investigate the structure-activity relationships of host-specific HMT- and PM-toxins, 8 mimics of PM-toxin A, a component of the host-specific corn pathotoxin produced by Phyllosticta maydis, were synthesized as stereoisomeric mixtures. All the mimics, except for PM-7137, had four β-ketol groups spaced by tri- and tetra-methylenes, which is shorter than the penta-methylenes involved in native PM-toxins. A comparison of their biological activity clearly demonstrated the general structural features necessary for potent activity: four β-ketol groups were necessary with a spacing of chains equal to or longer than penta-methylene.</description><identifier>ISSN: 0002-1369</identifier><identifier>DOI: 10.1080/00021369.1991.10870691</identifier><identifier>CODEN: ABCHA6</identifier><language>eng</language><publisher>Tokyo: Taylor & Francis</publisher><subject>Agronomy. Soil science and plant productions ; ALCOHOLES ; ALCOHOLS ; ALCOOL ; Biological and medical sciences ; BLIGHTS ; CETONAS ; CETONE ; CHEMICAL STRUCTURE ; CHEMICAL SYNTHESIS ; CYTOPLASMIC MALE STERILITY ; DEPERISSEMENT ; ESTERILIDAD MASCULINA CITOPLASMICA ; ESTRUCTURA QUIMICA ; FITOTOXICIDAD ; Fundamental and applied biological sciences. Psychology ; Fungal plant pathogens ; KETONES ; PHYLLOSTICTA ; Phytopathology. Animal pests. Plant and forest protection ; PHYTOTOXICITE ; PHYTOTOXICITY ; SINTESIS QUIMICA ; STERILITE MALE CYTOPLASMIQUE ; STRUCTURE CHIMIQUE ; SYNTHESE CHIMIQUE ; TIZON ; TOXINAS ; TOXINE ; TOXINS ; ZEA MAYS</subject><ispartof>Agricultural and biological chemistry, 1991-04, Vol.55 (4), p.1061-1070</ispartof><rights>Copyright, 1991, by the Japan Society for Bioscience, Biotechnology, and Agrochemistry 1991</rights><rights>1992 INIST-CNRS</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5314538$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Suzuki, Y. 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(Institute of Physical and Chemical Research, Wako, Saitama (Japan))</creatorcontrib><creatorcontrib>Kono, Y</creatorcontrib><creatorcontrib>Takahashi, Y</creatorcontrib><creatorcontrib>Suenaga, K</creatorcontrib><creatorcontrib>Daly, J.M</creatorcontrib><creatorcontrib>Knoche, H.W</creatorcontrib><creatorcontrib>Sakurai, A</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Agricultural and biological chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suzuki, Y. (Institute of Physical and Chemical Research, Wako, Saitama (Japan))</au><au>Kono, Y</au><au>Takahashi, Y</au><au>Suenaga, K</au><au>Daly, J.M</au><au>Knoche, H.W</au><au>Sakurai, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Toxic activity of mimics of the host-specific pathotoxin PM-toxin on corn carrying Texas male-sterile cytoplasm</atitle><jtitle>Agricultural and biological chemistry</jtitle><date>1991-04-01</date><risdate>1991</risdate><volume>55</volume><issue>4</issue><spage>1061</spage><epage>1070</epage><pages>1061-1070</pages><issn>0002-1369</issn><coden>ABCHA6</coden><abstract>To investigate the structure-activity relationships of host-specific HMT- and PM-toxins, 8 mimics of PM-toxin A, a component of the host-specific corn pathotoxin produced by Phyllosticta maydis, were synthesized as stereoisomeric mixtures. 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| ispartof | Agricultural and biological chemistry, 1991-04, Vol.55 (4), p.1061-1070 |
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| source | Free Full-Text Journals in Chemistry; EZB Electronic Journals Library; J-STAGE |
| subjects | Agronomy. Soil science and plant productions ALCOHOLES ALCOHOLS ALCOOL Biological and medical sciences BLIGHTS CETONAS CETONE CHEMICAL STRUCTURE CHEMICAL SYNTHESIS CYTOPLASMIC MALE STERILITY DEPERISSEMENT ESTERILIDAD MASCULINA CITOPLASMICA ESTRUCTURA QUIMICA FITOTOXICIDAD Fundamental and applied biological sciences. Psychology Fungal plant pathogens KETONES PHYLLOSTICTA Phytopathology. Animal pests. Plant and forest protection PHYTOTOXICITE PHYTOTOXICITY SINTESIS QUIMICA STERILITE MALE CYTOPLASMIQUE STRUCTURE CHIMIQUE SYNTHESE CHIMIQUE TIZON TOXINAS TOXINE TOXINS ZEA MAYS |
| title | Toxic activity of mimics of the host-specific pathotoxin PM-toxin on corn carrying Texas male-sterile cytoplasm |
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