Assessment of the In Vivo Mutagenic Potential of Methyl Tertiary-butyl Ether
Methyl tertiary‐butyl ether (MTBE) is one of the highest production volume chemicals in the USA. Previous results from in vitro genetic toxicity studies suggested that it was not mutagenic. However, chronic exposure at high levels resulted in liver tumors in female mice and kidney tumors in male rat...
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| Veröffentlicht in: | Journal of applied toxicology 1997-05, Vol.17 (S1), p.S31-S36 |
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| container_title | Journal of applied toxicology |
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| creator | McKee, Richard H. Vergnes, Jane S. Galvin, Jennifer B. Fielding Douglas, J. Kneiss, John J. Andrews, Larry S. |
| description | Methyl tertiary‐butyl ether (MTBE) is one of the highest production volume chemicals in the USA. Previous results from in vitro genetic toxicity studies suggested that it was not mutagenic. However, chronic exposure at high levels resulted in liver tumors in female mice and kidney tumors in male rats. The current program assessed in vivo genotoxicity and also explored the possibility that a mutagenic mechanism was involved in the carcinogenic process. The specific tests used included the Drosophila sex‐linked‐recessive‐lethal test, the rat bone marrow cytogenetics test, the mouse bone marrow micronucleus test and the in vivo–in vitro hepatocyte unscheduled DNA synthesis test in the mouse. All tests produced negative results, indicating that the potential for in vivo mutagenic activity was low. These data also suggest that the tumorigenic activity was probably the result of a non‐genotoxic process. © 1997 by John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/(SICI)1099-1263(199705)17:1+3.0.CO;2-A |
| format | Article |
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Appl. Toxicol</addtitle><description>Methyl tertiary‐butyl ether (MTBE) is one of the highest production volume chemicals in the USA. Previous results from in vitro genetic toxicity studies suggested that it was not mutagenic. However, chronic exposure at high levels resulted in liver tumors in female mice and kidney tumors in male rats. The current program assessed in vivo genotoxicity and also explored the possibility that a mutagenic mechanism was involved in the carcinogenic process. The specific tests used included the Drosophila sex‐linked‐recessive‐lethal test, the rat bone marrow cytogenetics test, the mouse bone marrow micronucleus test and the in vivo–in vitro hepatocyte unscheduled DNA synthesis test in the mouse. All tests produced negative results, indicating that the potential for in vivo mutagenic activity was low. 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| identifier | ISSN: 0260-437X |
| ispartof | Journal of applied toxicology, 1997-05, Vol.17 (S1), p.S31-S36 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Air Pollutants - toxicity Animals Bone Marrow - drug effects Carcinogens - toxicity DNA - biosynthesis Dose-Response Relationship, Drug Drosophila Drosophila melanogaster Female Liver - drug effects Male Methyl Ethers - toxicity methyl tertiary-butyl ether Mice Micronucleus Tests MTBE mutagenicity Mutagenicity Tests Rats Rats, Inbred F344 |
| title | Assessment of the In Vivo Mutagenic Potential of Methyl Tertiary-butyl Ether |
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