Once-daily dosing regimen for aminoglycoside plus β-Lactam combination therapy of serious bacterial infections: Comparative trial with netilmicin plus ceftriaxone

purpose: Once-daily dosing of aminoglycosides has been suggested to improve their efficacy and reduce their toxicity. To test the clinical validity of this suggestion, we conducted a prospective, randomized trial comparing a conventional multiple-daily-dosing regimen of netilmicin with once-daily ad...

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Veröffentlicht in:	The American journal of medicine 1990-07, Vol.89 (1), p.58-66
Hauptverfasser:	ter Braak, Edith W., de Vries, Peter J., Bouter, K.Paul, van der Vegt, Sytze G., Dorrestein, Gijsbert C., Nortier, Johannes W., van Dijk, Arie, Verkooyen, Roel P., Verbrugh, Henri A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Bacterial Infections - drug therapy Ceftriaxone - administration & dosage Ceftriaxone - adverse effects Ceftriaxone - therapeutic use Drug Administration Schedule Drug Therapy, Combination - administration & dosage Drug Therapy, Combination - adverse effects Drug Therapy, Combination - therapeutic use Female Humans Male Middle Aged Netilmicin - administration & dosage Netilmicin - adverse effects Netilmicin - therapeutic use Prospective Studies Randomized Controlled Trials as Topic
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