Protection against tetanus toxin in mice nasally immunized with recombinant Lactococcus lactis expressing tetanus toxin fragment C
Mice inoculated intranasally (i.n.) with a recombinant strain of live Lactococcus lactis expressing tetanus toxin fragment C (TTFC), produced both serum and secretory antibodies to TTFC. Killed bacteria which had accumulated TTFC intracellularly in vitro also elicited protective serum antibody respo...
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| Veröffentlicht in: | Vaccine 1997-04, Vol.15 (6), p.616-619 |
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| container_title | Vaccine |
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| creator | Norton, P.M. Wells, J.M. Brown, H.W.G. Macpherson, A.M. Le Page, R.W.F. |
| description | Mice inoculated intranasally (i.n.) with a recombinant strain of live
Lactococcus lactis expressing tetanus toxin fragment C (TTFC), produced both serum and secretory antibodies to TTFC. Killed bacteria which had accumulated TTFC intracellularly
in vitro also elicited protective serum antibody responses. There was no requirement for either colonization or invasion of the mucosa. In addition secretory antibody responses in the lung and nasal tissues were elicited after i.n. inoculation in the presence of an adjuvant. |
| doi_str_mv | 10.1016/S0264-410X(96)00241-1 |
| format | Article |
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Lactococcus lactis expressing tetanus toxin fragment C (TTFC), produced both serum and secretory antibodies to TTFC. Killed bacteria which had accumulated TTFC intracellularly
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Psychology</subject><subject>Genetic Vectors</subject><subject>Immunity, Mucosal</subject><subject>intranasal immunization</subject><subject>Lactococcus lactis</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Microbiology</subject><subject>mucosal immunization</subject><subject>Tetanus Antitoxin - blood</subject><subject>tetanus toxin</subject><subject>Tetanus Toxin - immunology</subject><subject>Tetanus Toxoid - immunology</subject><subject>vaccine</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</subject><subject>Vaccines, Synthetic - immunology</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMGKFDEQhoMo6-zqIyzkIKKH1iSdpJOTyKCrMKCggreQSarHSHcyJmnd9eiTm90Z5uBFCFSgvr-q-BC6pOQFJVS-_ESY5B2n5OszLZ8Twjjt6D20omroOyaouo9WJ-QhOi_lOyFE9FSfoTNNB8UlWaE_H3Oq4GpIEdudDbFUXKHauBRc03WIuL05OMDRFjtNNzjM8xLDb_D4V6jfcAaX5m2INla8sa4ml5xr4an9Q8Fwvc9QSoi7f8aO2e5maKH1I_RgtFOBx8d6gb68ffN5_a7bfLh6v3696RxnpHbAuGajFoMk1Pqtp2TglCpGmYKt63vCtJBec9Xb3luuRu0dt1rbBgklVX-Bnh7m7nP6sUCpZg7FwTTZCGkphkrCuRSkgeIAupxKyTCafQ6zzTeGEnPr3ty5N7dijZbmzr2hLXd5XLBsZ_Cn1FF26z859m1xdmoGogvlhDEpBj6Ihr06YNBk_AyQTXEBogMfmuxqfAr_OeQvgAGi0Q</recordid><startdate>19970401</startdate><enddate>19970401</enddate><creator>Norton, P.M.</creator><creator>Wells, J.M.</creator><creator>Brown, H.W.G.</creator><creator>Macpherson, A.M.</creator><creator>Le Page, R.W.F.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope></search><sort><creationdate>19970401</creationdate><title>Protection against tetanus toxin in mice nasally immunized with recombinant Lactococcus lactis expressing tetanus toxin fragment C</title><author>Norton, P.M. ; Wells, J.M. ; Brown, H.W.G. ; Macpherson, A.M. ; Le Page, R.W.F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-e2492f957601adbd10741182128ebc3302956d9483a3da48f9dc4a99a11858683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Administration, Intranasal</topic><topic>Animals</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Clostridium tetani</topic><topic>Fundamental and applied biological sciences. 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| fulltext | fulltext |
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| ispartof | Vaccine, 1997-04, Vol.15 (6), p.616-619 |
| issn | 0264-410X 1873-2518 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Administration, Intranasal Animals Bacteriology Biological and medical sciences Clostridium tetani Fundamental and applied biological sciences. Psychology Genetic Vectors Immunity, Mucosal intranasal immunization Lactococcus lactis Mice Mice, Inbred C57BL Microbiology mucosal immunization Tetanus Antitoxin - blood tetanus toxin Tetanus Toxin - immunology Tetanus Toxoid - immunology vaccine Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, Synthetic - immunology |
| title | Protection against tetanus toxin in mice nasally immunized with recombinant Lactococcus lactis expressing tetanus toxin fragment C |
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