Killing of Plasmodium falciparum by cytokine activated effector cells (neutrophils and macrophages)

Macrophages display natural antibody independent killing of asexual blood stages of Plasmodium falciparum in vitro. In contrast, the neutrophil killing of P. falciparum requires the presence of antibodies. Cytokines such as TNFα have very little effect on the macrophage-induced antiplasmodial activi...

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Veröffentlicht in:Immunology letters 1990-08, Vol.25 (1), p.179-187
Hauptverfasser: Ferrante, A., Kumaratilake, L., Rzepczyk, C.M., Dayer, J.-M.
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container_end_page 187
container_issue 1
container_start_page 179
container_title Immunology letters
container_volume 25
creator Ferrante, A.
Kumaratilake, L.
Rzepczyk, C.M.
Dayer, J.-M.
description Macrophages display natural antibody independent killing of asexual blood stages of Plasmodium falciparum in vitro. In contrast, the neutrophil killing of P. falciparum requires the presence of antibodies. Cytokines such as TNFα have very little effect on the macrophage-induced antiplasmodial activity, but significantly increase the damage of parasites by neutrophils. Cytokines, TNFα, IFN-γ and TNFβ at very high concentrations were not toxic to P. falciparum in culture. It is postulated that the basis for cytokine modulated antiplasmodial activity of leukocytes is increased expression of Fc and complement receptors, which leads to a more efficient interaction between the parasite and neutrophils. It is also postulated that the parasite evades natural macrophage killing mechanisms by inducing factors which supress this macrophage activity. Cytokine inhibitors may be induced during the course of a malarial infection. These could be involved in attempts to attain a balance between the host and the parasite, by protecting the parasite from the damaging effect of the immune system and protecting the host from the deleterious effects of cytokines.
doi_str_mv 10.1016/0165-2478(90)90112-4
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subjects Animals
Antibodies, Protozoan - biosynthesis
Biological and medical sciences
Cytokine
Cytokine inhibitor
Cytokines - physiology
Fundamental and applied biological sciences. Psychology
Host-Parasite Interactions - immunology
Humans
Immunity, Cellular
Interferon-gamma - physiology
Invertebrates
Life cycle. Host-agent relationship. Pathogenesis
Lymphotoxin-alpha - physiology
Macrophage
Macrophages - immunology
Malaria - blood
Malaria - immunology
Neutrophil
Neutrophils - immunology
Plasmodium falciparum
Plasmodium falciparum - immunology
Protozoa
Tumor Necrosis Factor-alpha - physiology
Tumour necrosis factor
title Killing of Plasmodium falciparum by cytokine activated effector cells (neutrophils and macrophages)
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