Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice

Targeted mutagenesis in mice, a powerful tool for the analysis of gene function and human disease, makes extensive use of 129 mouse substrains. Although all are named 129, we document that outcrossing of these substrains, both deliberate and accidental, has lead to extensive genetic variability amon...

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Veröffentlicht in:	Nature genetics 1997-05, Vol.16 (1), p.19-27
Hauptverfasser:	Simpson, Elizabeth M, Linder, Carol C, Sargent, Evelyn E, Davisson, Muriel T, Mobraaten, Larry E, Sharp, John J
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal Genetics and Genomics Animals Biological and medical sciences Biomarkers Biomedical and Life Sciences Biomedicine Cancer Research Cell Line Classical genetics, quantitative genetics, hybrids Crosses, Genetic Embryo, Mammalian - cytology Female Fundamental and applied biological sciences. Psychology Gene Function Genetic Variation Genetics of eukaryotes. Biological and molecular evolution Graft Rejection - genetics Human Genetics Male Mice Mice, Inbred C3H Mice, Inbred C57BL Mice, Inbred Strains - genetics Mice, Mutant Strains Mutagenesis new-technology Polymorphism, Genetic Proteins - genetics Skin Transplantation Stem Cells - cytology Vertebrata
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