Rapid Combinatorial Synthesis of Aminoglycoside Antibiotic Mimetics:  Use of a Polyethylene Glycol-Linked Amine and a Neamine-Derived Aldehyde in Multiple Component Condensation as a Strategy for the Discovery of New Inhibitors of the HIV RNA Rev Responsive Element

A library of neomycin B mimetics has been prepared rapidly without chromatography using a neamine-derived aldehyde, tert-butyl isocyanide or isocyanoacetic acid methyl ester, a glycine-conjugated polyethylene glycol (PEG) methyl ether, and various Cbz-N-protected amino acids as substrates in a Ugi-t...

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Veröffentlicht in:	Journal of the American Chemical Society 1996-10, Vol.118 (42), p.10150-10155
Hauptverfasser:	Park, William K. C., Auer, Manfred, Jaksche, Herbert, Wong, Chi-Huey
Format:	Artikel
Sprache:	eng
Schlagworte:	human immunodeficiency virus 1
Online-Zugang:	Volltext
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