Postnatal vaginal nodules induced by prenatal diethylstilbestrol treatment correlate with later development of ovary-independent vaginal and uterine changes in mice

Pregnant ICR JCL mice were given 4 daily subcutaneous injections of 0.2–2000 μg diethylstilbestrol (DES) starting on day 15 of gestation. Offspring of mothers given DES were killed at 1–10 days of age and examined for nodules of enlarged polygonal cells under the epithelium of the Müllerian (upper)...

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Veröffentlicht in:	Cancer letters 1991-07, Vol.58 (3), p.167-175
Hauptverfasser:	Ozawa, S., Iguchi, T., Sawada, K., Ohta, Y., Takasugi, N., Bern, H.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences diethylstilbestrol Diethylstilbestrol - adverse effects Dose-Response Relationship, Drug Drug toxicity and drugs side effects treatment epidermal growth factor Epidermal Growth Factor - biosynthesis Epithelium - drug effects Female female genital organs Maternal-Fetal Exchange Medical sciences Mice Mice, Inbred ICR neonatal treatment Organ Size - drug effects Pharmacology. Drug treatments Pregnancy Prenatal Exposure Delayed Effects Toxicity: urogenital system Uterus - drug effects Uterus - metabolism Uterus - pathology Vagina - drug effects Vagina - metabolism Vagina - pathology
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