Studies on the effect of peroxisomicine on catalase activity in albino mice
Peroxisomicine is a toxic compound isolated from plants of the genus Karwinskia (Rhamnaceae). This toxin produces irreversible and selective damage to the peroxisomes of yeast cells in vivo. Peroxisomicine also inhibits catalase activity in vitro, when using purified enzyme. This paper reports on th...
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| Veröffentlicht in: | Toxicon (Oxford) 1997-05, Vol.35 (5), p.777-783 |
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| container_title | Toxicon (Oxford) |
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| creator | Moreno-Sepúlveda, Myrthala Vargas-Zapata, Rigoberto Ballesteros-Elizondo, Raquel Piñeyro-López, Alfredo Sepúlveda-Saavedra, Julio |
| description | Peroxisomicine is a toxic compound isolated from plants of the genus
Karwinskia (Rhamnaceae). This toxin produces irreversible and selective damage to the peroxisomes of yeast cells
in vivo. Peroxisomicine also inhibits catalase activity
in vitro, when using purified enzyme. This paper reports on the effect of peroxisomicine on liver catalase in tissue fragments,
in situ, as well as in mice intoxicated with peroxisomicine,
in vivo. The catalase activity was determined by biochemical and histochemical methods. In contrast with the reported findings
in vitro, the results demonstrate that there is no inhibition of the activity of tissue catalase, and suggest that catalase
in situ and
in vivo is protected against the inhibitory effect of peroxisomicine by an unknown factor. |
| doi_str_mv | 10.1016/S0041-0101(96)00164-X |
| format | Article |
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Karwinskia (Rhamnaceae). This toxin produces irreversible and selective damage to the peroxisomes of yeast cells
in vivo. Peroxisomicine also inhibits catalase activity
in vitro, when using purified enzyme. This paper reports on the effect of peroxisomicine on liver catalase in tissue fragments,
in situ, as well as in mice intoxicated with peroxisomicine,
in vivo. The catalase activity was determined by biochemical and histochemical methods. In contrast with the reported findings
in vitro, the results demonstrate that there is no inhibition of the activity of tissue catalase, and suggest that catalase
in situ and
in vivo is protected against the inhibitory effect of peroxisomicine by an unknown factor.</description><identifier>ISSN: 0041-0101</identifier><identifier>EISSN: 1879-3150</identifier><identifier>DOI: 10.1016/S0041-0101(96)00164-X</identifier><identifier>PMID: 9203303</identifier><identifier>CODEN: TOXIA6</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Amitrole - toxicity ; Animals ; Anthracenes - toxicity ; Biological and medical sciences ; Catalase - metabolism ; Chemical Fractionation ; Cytosol - drug effects ; Cytosol - enzymology ; Liver - drug effects ; Liver - enzymology ; Liver - pathology ; Medical sciences ; Mice ; Microbodies - drug effects ; Microbodies - enzymology ; Microbodies - pathology ; Neurotoxins - toxicity ; Organelles - drug effects ; Organelles - enzymology ; Plant poisons toxicology ; Pyrans - toxicity ; Toxicology</subject><ispartof>Toxicon (Oxford), 1997-05, Vol.35 (5), p.777-783</ispartof><rights>1997</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-a325d72471829dbcf79984c6ded6361d7948c5397a5dd7e2188a2d98624738dd3</citedby><cites>FETCH-LOGICAL-c420t-a325d72471829dbcf79984c6ded6361d7948c5397a5dd7e2188a2d98624738dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S004101019600164X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2709223$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9203303$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moreno-Sepúlveda, Myrthala</creatorcontrib><creatorcontrib>Vargas-Zapata, Rigoberto</creatorcontrib><creatorcontrib>Ballesteros-Elizondo, Raquel</creatorcontrib><creatorcontrib>Piñeyro-López, Alfredo</creatorcontrib><creatorcontrib>Sepúlveda-Saavedra, Julio</creatorcontrib><title>Studies on the effect of peroxisomicine on catalase activity in albino mice</title><title>Toxicon (Oxford)</title><addtitle>Toxicon</addtitle><description>Peroxisomicine is a toxic compound isolated from plants of the genus
Karwinskia (Rhamnaceae). This toxin produces irreversible and selective damage to the peroxisomes of yeast cells
in vivo. Peroxisomicine also inhibits catalase activity
in vitro, when using purified enzyme. This paper reports on the effect of peroxisomicine on liver catalase in tissue fragments,
in situ, as well as in mice intoxicated with peroxisomicine,
in vivo. The catalase activity was determined by biochemical and histochemical methods. In contrast with the reported findings
in vitro, the results demonstrate that there is no inhibition of the activity of tissue catalase, and suggest that catalase
in situ and
in vivo is protected against the inhibitory effect of peroxisomicine by an unknown factor.</description><subject>Amitrole - toxicity</subject><subject>Animals</subject><subject>Anthracenes - toxicity</subject><subject>Biological and medical sciences</subject><subject>Catalase - metabolism</subject><subject>Chemical Fractionation</subject><subject>Cytosol - drug effects</subject><subject>Cytosol - enzymology</subject><subject>Liver - drug effects</subject><subject>Liver - enzymology</subject><subject>Liver - pathology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Microbodies - drug effects</subject><subject>Microbodies - enzymology</subject><subject>Microbodies - pathology</subject><subject>Neurotoxins - toxicity</subject><subject>Organelles - drug effects</subject><subject>Organelles - enzymology</subject><subject>Plant poisons toxicology</subject><subject>Pyrans - toxicity</subject><subject>Toxicology</subject><issn>0041-0101</issn><issn>1879-3150</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEURYMotVZ_gpCFiC5G8zGTSVYixS8UXKjQXUiTNxiZTmoyLfbfm9rSras8cs99CQehU0quKKHi-o2QkhYkzxdKXJJ8VRaTPTSkslYFpxXZR8MdcoiOUvoihHCpxAANFCOcEz5Ez2_9wnlIOHS4_wQMTQO2x6HBc4jhx6cw89Z3sM6t6U1rEmBje7_0_Qr7Dpt26ruAMwXH6KAxbYKT7TlCH_d37-PH4uX14Wl8-1LYkpG-MJxVrmZlTSVTbmqbWilZWuHACS6oq1UpbcVVbSrnamBUSsOckiJXuHSOj9D5Zu88hu8FpF7PfLLQtqaDsEiaCsIFVyqD1Qa0MaQUodHz6GcmrjQlei1R_0nUa0NaCf0nUU9y73T7wGI6A7drba3l_Gybm2RN20TTWZ92GKuJYmyN3WwwyDKWHqJO1kNnwfmYJWsX_D8f-QWihozv</recordid><startdate>19970501</startdate><enddate>19970501</enddate><creator>Moreno-Sepúlveda, Myrthala</creator><creator>Vargas-Zapata, Rigoberto</creator><creator>Ballesteros-Elizondo, Raquel</creator><creator>Piñeyro-López, Alfredo</creator><creator>Sepúlveda-Saavedra, Julio</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19970501</creationdate><title>Studies on the effect of peroxisomicine on catalase activity in albino mice</title><author>Moreno-Sepúlveda, Myrthala ; Vargas-Zapata, Rigoberto ; Ballesteros-Elizondo, Raquel ; Piñeyro-López, Alfredo ; Sepúlveda-Saavedra, Julio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-a325d72471829dbcf79984c6ded6361d7948c5397a5dd7e2188a2d98624738dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Amitrole - toxicity</topic><topic>Animals</topic><topic>Anthracenes - toxicity</topic><topic>Biological and medical sciences</topic><topic>Catalase - metabolism</topic><topic>Chemical Fractionation</topic><topic>Cytosol - drug effects</topic><topic>Cytosol - enzymology</topic><topic>Liver - drug effects</topic><topic>Liver - enzymology</topic><topic>Liver - pathology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Microbodies - drug effects</topic><topic>Microbodies - enzymology</topic><topic>Microbodies - pathology</topic><topic>Neurotoxins - toxicity</topic><topic>Organelles - drug effects</topic><topic>Organelles - enzymology</topic><topic>Plant poisons toxicology</topic><topic>Pyrans - toxicity</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moreno-Sepúlveda, Myrthala</creatorcontrib><creatorcontrib>Vargas-Zapata, Rigoberto</creatorcontrib><creatorcontrib>Ballesteros-Elizondo, Raquel</creatorcontrib><creatorcontrib>Piñeyro-López, Alfredo</creatorcontrib><creatorcontrib>Sepúlveda-Saavedra, Julio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Toxicon (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moreno-Sepúlveda, Myrthala</au><au>Vargas-Zapata, Rigoberto</au><au>Ballesteros-Elizondo, Raquel</au><au>Piñeyro-López, Alfredo</au><au>Sepúlveda-Saavedra, Julio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Studies on the effect of peroxisomicine on catalase activity in albino mice</atitle><jtitle>Toxicon (Oxford)</jtitle><addtitle>Toxicon</addtitle><date>1997-05-01</date><risdate>1997</risdate><volume>35</volume><issue>5</issue><spage>777</spage><epage>783</epage><pages>777-783</pages><issn>0041-0101</issn><eissn>1879-3150</eissn><coden>TOXIA6</coden><abstract>Peroxisomicine is a toxic compound isolated from plants of the genus
Karwinskia (Rhamnaceae). This toxin produces irreversible and selective damage to the peroxisomes of yeast cells
in vivo. Peroxisomicine also inhibits catalase activity
in vitro, when using purified enzyme. This paper reports on the effect of peroxisomicine on liver catalase in tissue fragments,
in situ, as well as in mice intoxicated with peroxisomicine,
in vivo. The catalase activity was determined by biochemical and histochemical methods. In contrast with the reported findings
in vitro, the results demonstrate that there is no inhibition of the activity of tissue catalase, and suggest that catalase
in situ and
in vivo is protected against the inhibitory effect of peroxisomicine by an unknown factor.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>9203303</pmid><doi>10.1016/S0041-0101(96)00164-X</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amitrole - toxicity Animals Anthracenes - toxicity Biological and medical sciences Catalase - metabolism Chemical Fractionation Cytosol - drug effects Cytosol - enzymology Liver - drug effects Liver - enzymology Liver - pathology Medical sciences Mice Microbodies - drug effects Microbodies - enzymology Microbodies - pathology Neurotoxins - toxicity Organelles - drug effects Organelles - enzymology Plant poisons toxicology Pyrans - toxicity Toxicology |
| title | Studies on the effect of peroxisomicine on catalase activity in albino mice |
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