Mutual requirement of CDK4 and Myc in malignant transformation: Evidence for cyclin D1/CDK4 and p16 super(INK4A) as upstream regulators of Myc

We demonstrate in this paper that CDK4 which is a G1 phase specific cell cycle regulator and catalytic subunit of D-type cyclins has oncogenic activity similar to D-type cyclins themselves and is able to provoke focus formation when cotransfected with activated Ha-ras into primary rat embryo fibrobl...

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Veröffentlicht in:	Oncogene 1997-07, Vol.15 (2), p.179-192
Hauptverfasser:	Haas, K, Staller, P, Geisen, C, Bartek, J, Eilers, M, Moeroey, T
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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