Interferon-γ Modulates a p53-independent Apoptotic Pathway and Apoptosis-related Gene Expression

Interferon (IFN)-γ increases the sensitivity of tumor cell lines, many of which are p53 mutants, to tumor necrosis factor-α-mediated and anti-Fas antibody-mediated cell death. To better understand the mechanism of IFN-γ action in modulating the cell death response independently of p53 function, we a...

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Veröffentlicht in:	The Journal of biological chemistry 1997-06, Vol.272 (26), p.16351-16357
Hauptverfasser:	Ossina, Natalya K., Cannas, Angela, Powers, Virginia C., Fitzpatrick, Paul A., Knight, John D., Gilbert, James R., Shekhtman, Eugene M., Tomei, L. David, Umansky, Samuil R., Kiefer, Michael C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Cycloheximide - pharmacology DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene Expression Regulation - drug effects HT29 Cells Humans Interferon Regulatory Factor-1 Interferon-gamma - pharmacology Phosphoproteins - genetics Phosphoproteins - metabolism Proto-Oncogene Proteins c-bcl-2 - analysis Proto-Oncogene Proteins c-bcl-2 - genetics RNA, Messenger - analysis Tumor Suppressor Protein p53 - physiology
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