Inhibition of γ-glutamyl transpeptidase potentiates the nephrotoxicity of glutathione-conjugated chlorohydroquinones

Administration of either 2,5-dichloro-3-(glutathion- S-yl)-1,4-benzoquinone (DC-[GSyl]BQ) or 2,5,6-trichloro-3-(glutathion- S-yl)-1,4-benzoquinone (TC-[GSyl]BQ) to male Sprague-Dawley rats caused dose-dependent (50–200 μmol/kg; iv) renal proximal tubular necrosis, as evidenced by elevations in blood...

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Veröffentlicht in:	Toxicology and applied pharmacology 1991-08, Vol.110 (1), p.45-60
Hauptverfasser:	Mertens, Jos J.W.M., Temmink, Johan H.M., van Bladeren, Peter J., Jones, Thomas W., Lo, Herng-Hsiang, Lau, Serrine S., Monks, Terrence J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ascorbic Acid - pharmacology Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Chloranil - analogs & derivatives Chloranil - toxicity Chromatography, High Pressure Liquid COMPOSE ORGANOCHLORE COMPUESTO ORGANICO DEL CLORO DESINTOXICACION DETOXIFICATION Dose-Response Relationship, Drug Drug Synergism Electrochemistry gamma-Glutamyltransferase - antagonists & inhibitors Glutathione - analogs & derivatives Glutathione - toxicity Isoxazoles - pharmacology Kidney Cortex - drug effects Kidney Cortex - pathology Kidney Diseases - chemically induced Kidney Diseases - pathology Kidney Tubular Necrosis, Acute - chemically induced Male Medical sciences METABOLISME METABOLISMO Oxidation-Reduction PEPTIDASAS PEPTIDASE PEPTIDE PEPTIDOS QUINONAS QUINONE RAT RATA Rats Rats, Inbred Strains REIN RINONES TOXICIDAD TOXICITE Toxicology Various organic compounds
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