Cytokine-induced activation of the neuroendocrine stress axis persists in endotoxin-tolerant mice

Chronic administration of lipopolysaccharide (LPS) to mice markedly reduced activation of the neuroendocrine stress axis elicited by an acute challenge dose of LPS. LPS-induced elevation in norepinephrine turnover in the hypothalamus showed complete tolerance whereas elevation of plasma corticostero...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Brain research 1991-08, Vol.557 (1), p.327-330
Hauptverfasser:	Mefford, Ivan N., Masters, Carolyn F., Heyes, Melvyn P., Eskay, Robert L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biogenic Monoamines - metabolism Biological and medical sciences Corticosterone Corticosterone - metabolism Cytokines - pharmacology Dopamine - metabolism Drug Tolerance Endotoxins - toxicity Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Hypothalamus Hypothalamus - drug effects Hypothalamus - metabolism Interleukin-1 - pharmacology Lipopolysaccharide Lipopolysaccharides - toxicity Macrophages - drug effects Male Mice Mice, Inbred C57BL Neuroendocrine stress axis Neurosecretory Systems - drug effects Neurosecretory Systems - physiology Noradrenaline Norepinephrine - metabolism Stress, Physiological - physiopathology Tumor Necrosis Factor-alpha - pharmacology Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!