Calcitonin gene-related peptide, neurokinin A and substance P: Effects on Nociception and neurogenic inflammation in human skin and temporal muscle
Calcitonin gene-related peptide (CGRP) was injected alone and in combination with substance P (SP) or neurokinin A (NKA) into the foream skin and temporal muscle of human volunteers. In the skin, 50 pmol of CGRP induced a wheal response and a delayed erythema. No pain was recorded. No interaction be...
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| Veröffentlicht in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1991-03, Vol.12 (2), p.333-337 |
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| creator | Pedersen-Bjergaard, Ulrik Nielsen, Lars Bøgeskov Jensen, Kai Edvinsson, Lars Jansen, Inger Olesen, Jes |
| description | Calcitonin gene-related peptide (CGRP) was injected alone and in combination with substance P (SP) or neurokinin A (NKA) into the foream skin and temporal muscle of human volunteers. In the skin, 50 pmol of CGRP induced a wheal response and a delayed erythema. No pain was recorded. No interaction between CGRP and SP or NKA was observed. In the temporal muscle, 200 pmol of CGRP alone did not induce pain or tenderness but, in combination with SP or NKA, CGRP elicited a significant pain sensation. It is concluded that CGRP may be involved in neurogenic inflammation and that only SP, of the three peptides present in nociceptive C fibers, seems to be of major importance in relation to cutaneous nociception. Simultaneous neurogenic release of CGRP and other neuropeptides in skeletal muscle may induce myofascial pain. |
| doi_str_mv | 10.1016/0196-9781(91)90022-H |
| format | Article |
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In the skin, 50 pmol of CGRP induced a wheal response and a delayed erythema. No pain was recorded. No interaction between CGRP and SP or NKA was observed. In the temporal muscle, 200 pmol of CGRP alone did not induce pain or tenderness but, in combination with SP or NKA, CGRP elicited a significant pain sensation. It is concluded that CGRP may be involved in neurogenic inflammation and that only SP, of the three peptides present in nociceptive C fibers, seems to be of major importance in relation to cutaneous nociception. Simultaneous neurogenic release of CGRP and other neuropeptides in skeletal muscle may induce myofascial pain.</description><identifier>ISSN: 0196-9781</identifier><identifier>EISSN: 1873-5169</identifier><identifier>DOI: 10.1016/0196-9781(91)90022-H</identifier><identifier>PMID: 1712469</identifier><identifier>CODEN: PPTDD5</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Calcitonin gene-related peptide ; Calcitonin Gene-Related Peptide - pharmacology ; Calcitonin Gene-Related Peptide - physiology ; Drug Interactions ; Female ; Flare ; Fundamental and applied biological sciences. Psychology ; Humans ; Inflammation - etiology ; Male ; Muscles - drug effects ; Muscles - physiology ; Muscular tenderness ; Neurogenic inflammation ; Neurokinin A ; Neurokinin A - pharmacology ; Neurokinin A - physiology ; Neuropeptides - pharmacology ; Neuropeptides - physiology ; Nociception ; Nociceptors - drug effects ; Nociceptors - physiology ; Skin - drug effects ; Skin Physiological Phenomena ; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors ; Substance P ; Substance P - pharmacology ; Substance P - physiology ; Vertebrates: nervous system and sense organs ; Wheal</subject><ispartof>Peptides (New York, N.Y. : 1980), 1991-03, Vol.12 (2), p.333-337</ispartof><rights>1991</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c484t-46dfd3bf883feaec742d6884b13ec837aa95bc75f9d5d1a1a2954a118207ec993</citedby><cites>FETCH-LOGICAL-c484t-46dfd3bf883feaec742d6884b13ec837aa95bc75f9d5d1a1a2954a118207ec993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0196-9781(91)90022-H$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19617560$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1712469$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pedersen-Bjergaard, Ulrik</creatorcontrib><creatorcontrib>Nielsen, Lars Bøgeskov</creatorcontrib><creatorcontrib>Jensen, Kai</creatorcontrib><creatorcontrib>Edvinsson, Lars</creatorcontrib><creatorcontrib>Jansen, Inger</creatorcontrib><creatorcontrib>Olesen, Jes</creatorcontrib><title>Calcitonin gene-related peptide, neurokinin A and substance P: Effects on Nociception and neurogenic inflammation in human skin and temporal muscle</title><title>Peptides (New York, N.Y. : 1980)</title><addtitle>Peptides</addtitle><description>Calcitonin gene-related peptide (CGRP) was injected alone and in combination with substance P (SP) or neurokinin A (NKA) into the foream skin and temporal muscle of human volunteers. In the skin, 50 pmol of CGRP induced a wheal response and a delayed erythema. No pain was recorded. No interaction between CGRP and SP or NKA was observed. In the temporal muscle, 200 pmol of CGRP alone did not induce pain or tenderness but, in combination with SP or NKA, CGRP elicited a significant pain sensation. It is concluded that CGRP may be involved in neurogenic inflammation and that only SP, of the three peptides present in nociceptive C fibers, seems to be of major importance in relation to cutaneous nociception. Simultaneous neurogenic release of CGRP and other neuropeptides in skeletal muscle may induce myofascial pain.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Calcitonin gene-related peptide</subject><subject>Calcitonin Gene-Related Peptide - pharmacology</subject><subject>Calcitonin Gene-Related Peptide - physiology</subject><subject>Drug Interactions</subject><subject>Female</subject><subject>Flare</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Inflammation - etiology</subject><subject>Male</subject><subject>Muscles - drug effects</subject><subject>Muscles - physiology</subject><subject>Muscular tenderness</subject><subject>Neurogenic inflammation</subject><subject>Neurokinin A</subject><subject>Neurokinin A - pharmacology</subject><subject>Neurokinin A - physiology</subject><subject>Neuropeptides - pharmacology</subject><subject>Neuropeptides - physiology</subject><subject>Nociception</subject><subject>Nociceptors - drug effects</subject><subject>Nociceptors - physiology</subject><subject>Skin - drug effects</subject><subject>Skin Physiological Phenomena</subject><subject>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</subject><subject>Substance P</subject><subject>Substance P - pharmacology</subject><subject>Substance P - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Wheal</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kVGL1DAUhYMo6zj6DxTyoihsNWnTNvFBWIZ1Z2FRH_Q53CY3Gm3TbtIK_g7_sOnM4L4tJCRwvnO4nEvIc87ecsabd4yrplCt5K8Vf6MYK8ti_4BsuGyrouaNekg2_5HH5ElKPxljQih5Rs54y0vRqA35u4Pe-HkMPtDvGLCI2MOMlk44zd7iOQ24xPGXX4ELCsHStHRphmCQfnlPL51DMyc6BvppNN6srvxfuYMxZ3pDfXA9DAMctBz0Yxkg0JRTD-SMwzRG6OmwJNPjU_LIQZ_w2endkm8fL7_u9sXN56vr3cVNYYQUcyEa62zVOSkrh4CmFaVtpBQdr9DIqgVQdWfa2ilbWw4cSlUL4FyWrEWjVLUlr465UxxvF0yzHnwy2PcQcFyS5g0rqzLfLRFH0MQxpYhOT9EPEP9ozvS6C70Wrdeitcpn3YXeZ9uLU_7SDWjvTMfys_7ypEMy0LuYS_XpDlMNb-uGZe7DkcNcxm-PUSfjMS_A-pjL13b09w_yD8rmqEE</recordid><startdate>19910301</startdate><enddate>19910301</enddate><creator>Pedersen-Bjergaard, Ulrik</creator><creator>Nielsen, Lars Bøgeskov</creator><creator>Jensen, Kai</creator><creator>Edvinsson, Lars</creator><creator>Jansen, Inger</creator><creator>Olesen, Jes</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19910301</creationdate><title>Calcitonin gene-related peptide, neurokinin A and substance P: Effects on Nociception and neurogenic inflammation in human skin and temporal muscle</title><author>Pedersen-Bjergaard, Ulrik ; Nielsen, Lars Bøgeskov ; Jensen, Kai ; Edvinsson, Lars ; Jansen, Inger ; Olesen, Jes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-46dfd3bf883feaec742d6884b13ec837aa95bc75f9d5d1a1a2954a118207ec993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Calcitonin gene-related peptide</topic><topic>Calcitonin Gene-Related Peptide - pharmacology</topic><topic>Calcitonin Gene-Related Peptide - physiology</topic><topic>Drug Interactions</topic><topic>Female</topic><topic>Flare</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Inflammation - etiology</topic><topic>Male</topic><topic>Muscles - drug effects</topic><topic>Muscles - physiology</topic><topic>Muscular tenderness</topic><topic>Neurogenic inflammation</topic><topic>Neurokinin A</topic><topic>Neurokinin A - pharmacology</topic><topic>Neurokinin A - physiology</topic><topic>Neuropeptides - pharmacology</topic><topic>Neuropeptides - physiology</topic><topic>Nociception</topic><topic>Nociceptors - drug effects</topic><topic>Nociceptors - physiology</topic><topic>Skin - drug effects</topic><topic>Skin Physiological Phenomena</topic><topic>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</topic><topic>Substance P</topic><topic>Substance P - pharmacology</topic><topic>Substance P - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Wheal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pedersen-Bjergaard, Ulrik</creatorcontrib><creatorcontrib>Nielsen, Lars Bøgeskov</creatorcontrib><creatorcontrib>Jensen, Kai</creatorcontrib><creatorcontrib>Edvinsson, Lars</creatorcontrib><creatorcontrib>Jansen, Inger</creatorcontrib><creatorcontrib>Olesen, Jes</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Peptides (New York, N.Y. : 1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pedersen-Bjergaard, Ulrik</au><au>Nielsen, Lars Bøgeskov</au><au>Jensen, Kai</au><au>Edvinsson, Lars</au><au>Jansen, Inger</au><au>Olesen, Jes</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Calcitonin gene-related peptide, neurokinin A and substance P: Effects on Nociception and neurogenic inflammation in human skin and temporal muscle</atitle><jtitle>Peptides (New York, N.Y. : 1980)</jtitle><addtitle>Peptides</addtitle><date>1991-03-01</date><risdate>1991</risdate><volume>12</volume><issue>2</issue><spage>333</spage><epage>337</epage><pages>333-337</pages><issn>0196-9781</issn><eissn>1873-5169</eissn><coden>PPTDD5</coden><abstract>Calcitonin gene-related peptide (CGRP) was injected alone and in combination with substance P (SP) or neurokinin A (NKA) into the foream skin and temporal muscle of human volunteers. In the skin, 50 pmol of CGRP induced a wheal response and a delayed erythema. No pain was recorded. No interaction between CGRP and SP or NKA was observed. In the temporal muscle, 200 pmol of CGRP alone did not induce pain or tenderness but, in combination with SP or NKA, CGRP elicited a significant pain sensation. It is concluded that CGRP may be involved in neurogenic inflammation and that only SP, of the three peptides present in nociceptive C fibers, seems to be of major importance in relation to cutaneous nociception. Simultaneous neurogenic release of CGRP and other neuropeptides in skeletal muscle may induce myofascial pain.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>1712469</pmid><doi>10.1016/0196-9781(91)90022-H</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0196-9781 |
| ispartof | Peptides (New York, N.Y. : 1980), 1991-03, Vol.12 (2), p.333-337 |
| issn | 0196-9781 1873-5169 |
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| subjects | Adult Biological and medical sciences Calcitonin gene-related peptide Calcitonin Gene-Related Peptide - pharmacology Calcitonin Gene-Related Peptide - physiology Drug Interactions Female Flare Fundamental and applied biological sciences. Psychology Humans Inflammation - etiology Male Muscles - drug effects Muscles - physiology Muscular tenderness Neurogenic inflammation Neurokinin A Neurokinin A - pharmacology Neurokinin A - physiology Neuropeptides - pharmacology Neuropeptides - physiology Nociception Nociceptors - drug effects Nociceptors - physiology Skin - drug effects Skin Physiological Phenomena Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Substance P Substance P - pharmacology Substance P - physiology Vertebrates: nervous system and sense organs Wheal |
| title | Calcitonin gene-related peptide, neurokinin A and substance P: Effects on Nociception and neurogenic inflammation in human skin and temporal muscle |
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