The immunosuppressant FK-506 prevents progression of diabetes in nonobese diabetic mice

A novel immunosuppressive compound, FK-506, isolated from Streptomyces has potent immunosuppressive activities. To investigate the effect of FK-506 on the course of diabetes in nonobese diabetic (NOD) mice, we gave this drug to these animals, from the age of 8 weeks, intraperitoneally, in doses of 0...

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Veröffentlicht in:	Clinical immunology and immunopathology 1990-11, Vol.57 (2), p.274-279
Hauptverfasser:	Kurasawa, Kazuhiro, Koike, Takao, Matsumura, Ryutaro, Takabayashi, Katsuhiko, Tomioka, Hisao, Ito, Isao, Yoshida, Sho
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - therapeutic use Antigens, Surface - analysis Biological and medical sciences Diabetes Mellitus, Type 1 - drug therapy Diabetes Mellitus, Type 1 - pathology Diabetes Mellitus, Type 1 - prevention & control Female Immunomodulators Immunosuppressive Agents - therapeutic use Medical sciences Mice Mice, Obese Pharmacology. Drug treatments Spleen - cytology Spleen - immunology Tacrolimus Weight Loss
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