A novel process for preparing an acellular pertussis vaccine composed of non-pyrogenic toxoids of pertussis toxin and filamentous hemagglutinin

A novel process for preparing non-pyrogenic toxoids of pertussis toxin (PT) and filamentous hemagglutinin (FHA) is described. The process consists of chromatographies on perlite then on hydroxylapatite. Purification yields for PT and FHA are 62 and 68%, respectively. The purification process takes a...

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Veröffentlicht in:	Molecular immunology 1991-03, Vol.28 (3), p.251-255
Hauptverfasser:	Tan, Larry U.L., Fahim, Raafat E.F., Jackson, Gail, Phillips, Kimberly, Wah, Po, Alkema, Dirk, Zobrist, Gloria, Herbert, Andrew, Boux, Leslie, Chong, Pele, Harjee, Nadir, Klein, Michel, Vose, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Bordetella pertussis - analysis Bordetella pertussis - immunology Hemagglutinins - immunology Hemagglutinins - isolation & purification Molecular Weight Pertussis Toxin Pertussis Vaccine - immunology Pyrogens - analysis Virulence Factors, Bordetella - immunology Virulence Factors, Bordetella - isolation & purification
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