ω-Conotoxin GVIA and desipramine insensitive norepinephrine efflux from cardiac sympathetic nerve terminal
Using dialysis technique, prominent accumulation of norepinephrine (NE) in the myocardial interstitial space was observed under local administration of a monoamine oxidase inhibitor (pargyline, 10 mM), and a vesicle uptake inhibitor (reserpine, 10 μM). Accumulation of NE in the myocardial interstiti...
Gespeichert in:
| Veröffentlicht in: | Brain research 1997-07, Vol.761 (2), p.329-332 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 332 |
|---|---|
| container_issue | 2 |
| container_start_page | 329 |
| container_title | Brain research |
| container_volume | 761 |
| creator | Yamazaki, Toji Kawada, Toru Akiyama, Tsuyoshi Kitagawa, Hirotoshi Takauchi, Yuji Yahagi, Naoki Sunagawa, Kenji |
| description | Using dialysis technique, prominent accumulation of norepinephrine (NE) in the myocardial interstitial space was observed under local administration of a monoamine oxidase inhibitor (pargyline, 10 mM), and a vesicle uptake inhibitor (reserpine, 10 μM). Accumulation of NE in the myocardial interstitial space was associated with a reduction of dihydroxyphenylglycol levels. Pretreatment with ω-conotoxin GVIA (10 μM) or desipramine (10 μM) did not suppress this response. A brisk increase in dialysate NE levels might occur as a consequence of exocytotic or neurotransporter insensitive efflux of NE. |
| doi_str_mv | 10.1016/S0006-8993(97)00443-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_16014569</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006899397004435</els_id><sourcerecordid>16014569</sourcerecordid><originalsourceid>FETCH-LOGICAL-c391t-b87707c7a54b4eb97e24a953cc01d7f088a3f8832e5888d5a32c97208990367c3</originalsourceid><addsrcrecordid>eNqFkMtOBCEQRYnR6Pj4BBNWRhet0DQNrIyZ-EpMXPjYEoaujmg3tNAz0U_w6_wlGWfi1hVF3XurUgehQ0pOKaH12QMhpC6kUuxYiRNCqooVfANNqBRlUZcV2USTP8sO2k3pNX8ZU2QbbauSl7meoLfvr2IafBjDh_P4-vn2Ahvf4AaSG6LpnQfsfAKf3OgWgH2IMOTm8BKXErRtN__AbQw9tiY2zlicPvvBjC8wOos9xBwaIeZBpttHW63pEhys3z30dHX5OL0p7u6vb6cXd4Vlio7FTApBhBWGV7MKZkpAWRnFmbWENqIlUhrWSslK4FLKhhtWWiVKku8krBaW7aGj1dwhhvc5pFH3LlnoOuMhzJOmNaEVr1U28pXRxpBShFYP0fUmfmpK9BKy_oWslwS1EvoXsuY5d7heMJ_10Pyl1lSzfr7SIV-5cBB1sg68hcZFsKNugvtnww_2fY2p</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16014569</pqid></control><display><type>article</type><title>ω-Conotoxin GVIA and desipramine insensitive norepinephrine efflux from cardiac sympathetic nerve terminal</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Yamazaki, Toji ; Kawada, Toru ; Akiyama, Tsuyoshi ; Kitagawa, Hirotoshi ; Takauchi, Yuji ; Yahagi, Naoki ; Sunagawa, Kenji</creator><creatorcontrib>Yamazaki, Toji ; Kawada, Toru ; Akiyama, Tsuyoshi ; Kitagawa, Hirotoshi ; Takauchi, Yuji ; Yahagi, Naoki ; Sunagawa, Kenji</creatorcontrib><description>Using dialysis technique, prominent accumulation of norepinephrine (NE) in the myocardial interstitial space was observed under local administration of a monoamine oxidase inhibitor (pargyline, 10 mM), and a vesicle uptake inhibitor (reserpine, 10 μM). Accumulation of NE in the myocardial interstitial space was associated with a reduction of dihydroxyphenylglycol levels. Pretreatment with ω-conotoxin GVIA (10 μM) or desipramine (10 μM) did not suppress this response. A brisk increase in dialysate NE levels might occur as a consequence of exocytotic or neurotransporter insensitive efflux of NE.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/S0006-8993(97)00443-5</identifier><identifier>PMID: 9252033</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adrenergic Fibers - drug effects ; Adrenergic Fibers - metabolism ; Adrenergic Uptake Inhibitors - pharmacology ; Animals ; Calcium Channel Blockers - pharmacology ; Cats ; Desipramine - pharmacology ; Female ; Heart - innervation ; Male ; Monoamine Oxidase Inhibitors - pharmacology ; Neurotransporter ; Non-exocytotic release ; Noradrenaline ; Norepinephrine - metabolism ; omega-Conotoxin GVIA ; Pargyline ; Pargyline - pharmacology ; Peptides - pharmacology ; Presynaptic Terminals - drug effects ; Presynaptic Terminals - metabolism ; Reserpine ; Reserpine - pharmacology</subject><ispartof>Brain research, 1997-07, Vol.761 (2), p.329-332</ispartof><rights>1997</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-b87707c7a54b4eb97e24a953cc01d7f088a3f8832e5888d5a32c97208990367c3</citedby><cites>FETCH-LOGICAL-c391t-b87707c7a54b4eb97e24a953cc01d7f088a3f8832e5888d5a32c97208990367c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006899397004435$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9252033$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamazaki, Toji</creatorcontrib><creatorcontrib>Kawada, Toru</creatorcontrib><creatorcontrib>Akiyama, Tsuyoshi</creatorcontrib><creatorcontrib>Kitagawa, Hirotoshi</creatorcontrib><creatorcontrib>Takauchi, Yuji</creatorcontrib><creatorcontrib>Yahagi, Naoki</creatorcontrib><creatorcontrib>Sunagawa, Kenji</creatorcontrib><title>ω-Conotoxin GVIA and desipramine insensitive norepinephrine efflux from cardiac sympathetic nerve terminal</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Using dialysis technique, prominent accumulation of norepinephrine (NE) in the myocardial interstitial space was observed under local administration of a monoamine oxidase inhibitor (pargyline, 10 mM), and a vesicle uptake inhibitor (reserpine, 10 μM). Accumulation of NE in the myocardial interstitial space was associated with a reduction of dihydroxyphenylglycol levels. Pretreatment with ω-conotoxin GVIA (10 μM) or desipramine (10 μM) did not suppress this response. A brisk increase in dialysate NE levels might occur as a consequence of exocytotic or neurotransporter insensitive efflux of NE.</description><subject>Adrenergic Fibers - drug effects</subject><subject>Adrenergic Fibers - metabolism</subject><subject>Adrenergic Uptake Inhibitors - pharmacology</subject><subject>Animals</subject><subject>Calcium Channel Blockers - pharmacology</subject><subject>Cats</subject><subject>Desipramine - pharmacology</subject><subject>Female</subject><subject>Heart - innervation</subject><subject>Male</subject><subject>Monoamine Oxidase Inhibitors - pharmacology</subject><subject>Neurotransporter</subject><subject>Non-exocytotic release</subject><subject>Noradrenaline</subject><subject>Norepinephrine - metabolism</subject><subject>omega-Conotoxin GVIA</subject><subject>Pargyline</subject><subject>Pargyline - pharmacology</subject><subject>Peptides - pharmacology</subject><subject>Presynaptic Terminals - drug effects</subject><subject>Presynaptic Terminals - metabolism</subject><subject>Reserpine</subject><subject>Reserpine - pharmacology</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOBCEQRYnR6Pj4BBNWRhet0DQNrIyZ-EpMXPjYEoaujmg3tNAz0U_w6_wlGWfi1hVF3XurUgehQ0pOKaH12QMhpC6kUuxYiRNCqooVfANNqBRlUZcV2USTP8sO2k3pNX8ZU2QbbauSl7meoLfvr2IafBjDh_P4-vn2Ahvf4AaSG6LpnQfsfAKf3OgWgH2IMOTm8BKXErRtN__AbQw9tiY2zlicPvvBjC8wOos9xBwaIeZBpttHW63pEhys3z30dHX5OL0p7u6vb6cXd4Vlio7FTApBhBWGV7MKZkpAWRnFmbWENqIlUhrWSslK4FLKhhtWWiVKku8krBaW7aGj1dwhhvc5pFH3LlnoOuMhzJOmNaEVr1U28pXRxpBShFYP0fUmfmpK9BKy_oWslwS1EvoXsuY5d7heMJ_10Pyl1lSzfr7SIV-5cBB1sg68hcZFsKNugvtnww_2fY2p</recordid><startdate>19970704</startdate><enddate>19970704</enddate><creator>Yamazaki, Toji</creator><creator>Kawada, Toru</creator><creator>Akiyama, Tsuyoshi</creator><creator>Kitagawa, Hirotoshi</creator><creator>Takauchi, Yuji</creator><creator>Yahagi, Naoki</creator><creator>Sunagawa, Kenji</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19970704</creationdate><title>ω-Conotoxin GVIA and desipramine insensitive norepinephrine efflux from cardiac sympathetic nerve terminal</title><author>Yamazaki, Toji ; Kawada, Toru ; Akiyama, Tsuyoshi ; Kitagawa, Hirotoshi ; Takauchi, Yuji ; Yahagi, Naoki ; Sunagawa, Kenji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-b87707c7a54b4eb97e24a953cc01d7f088a3f8832e5888d5a32c97208990367c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adrenergic Fibers - drug effects</topic><topic>Adrenergic Fibers - metabolism</topic><topic>Adrenergic Uptake Inhibitors - pharmacology</topic><topic>Animals</topic><topic>Calcium Channel Blockers - pharmacology</topic><topic>Cats</topic><topic>Desipramine - pharmacology</topic><topic>Female</topic><topic>Heart - innervation</topic><topic>Male</topic><topic>Monoamine Oxidase Inhibitors - pharmacology</topic><topic>Neurotransporter</topic><topic>Non-exocytotic release</topic><topic>Noradrenaline</topic><topic>Norepinephrine - metabolism</topic><topic>omega-Conotoxin GVIA</topic><topic>Pargyline</topic><topic>Pargyline - pharmacology</topic><topic>Peptides - pharmacology</topic><topic>Presynaptic Terminals - drug effects</topic><topic>Presynaptic Terminals - metabolism</topic><topic>Reserpine</topic><topic>Reserpine - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamazaki, Toji</creatorcontrib><creatorcontrib>Kawada, Toru</creatorcontrib><creatorcontrib>Akiyama, Tsuyoshi</creatorcontrib><creatorcontrib>Kitagawa, Hirotoshi</creatorcontrib><creatorcontrib>Takauchi, Yuji</creatorcontrib><creatorcontrib>Yahagi, Naoki</creatorcontrib><creatorcontrib>Sunagawa, Kenji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamazaki, Toji</au><au>Kawada, Toru</au><au>Akiyama, Tsuyoshi</au><au>Kitagawa, Hirotoshi</au><au>Takauchi, Yuji</au><au>Yahagi, Naoki</au><au>Sunagawa, Kenji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ω-Conotoxin GVIA and desipramine insensitive norepinephrine efflux from cardiac sympathetic nerve terminal</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1997-07-04</date><risdate>1997</risdate><volume>761</volume><issue>2</issue><spage>329</spage><epage>332</epage><pages>329-332</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><abstract>Using dialysis technique, prominent accumulation of norepinephrine (NE) in the myocardial interstitial space was observed under local administration of a monoamine oxidase inhibitor (pargyline, 10 mM), and a vesicle uptake inhibitor (reserpine, 10 μM). Accumulation of NE in the myocardial interstitial space was associated with a reduction of dihydroxyphenylglycol levels. Pretreatment with ω-conotoxin GVIA (10 μM) or desipramine (10 μM) did not suppress this response. A brisk increase in dialysate NE levels might occur as a consequence of exocytotic or neurotransporter insensitive efflux of NE.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>9252033</pmid><doi>10.1016/S0006-8993(97)00443-5</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-8993 |
| ispartof | Brain research, 1997-07, Vol.761 (2), p.329-332 |
| issn | 0006-8993 1872-6240 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_16014569 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adrenergic Fibers - drug effects Adrenergic Fibers - metabolism Adrenergic Uptake Inhibitors - pharmacology Animals Calcium Channel Blockers - pharmacology Cats Desipramine - pharmacology Female Heart - innervation Male Monoamine Oxidase Inhibitors - pharmacology Neurotransporter Non-exocytotic release Noradrenaline Norepinephrine - metabolism omega-Conotoxin GVIA Pargyline Pargyline - pharmacology Peptides - pharmacology Presynaptic Terminals - drug effects Presynaptic Terminals - metabolism Reserpine Reserpine - pharmacology |
| title | ω-Conotoxin GVIA and desipramine insensitive norepinephrine efflux from cardiac sympathetic nerve terminal |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T16%3A10%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=%CF%89-Conotoxin%20GVIA%20and%20desipramine%20insensitive%20norepinephrine%20efflux%20from%20cardiac%20sympathetic%20nerve%20terminal&rft.jtitle=Brain%20research&rft.au=Yamazaki,%20Toji&rft.date=1997-07-04&rft.volume=761&rft.issue=2&rft.spage=329&rft.epage=332&rft.pages=329-332&rft.issn=0006-8993&rft.eissn=1872-6240&rft_id=info:doi/10.1016/S0006-8993(97)00443-5&rft_dat=%3Cproquest_cross%3E16014569%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16014569&rft_id=info:pmid/9252033&rft_els_id=S0006899397004435&rfr_iscdi=true |