Effects of repeated injections of palytoxin on lymphoid tissues in mice

Sublethal doses of palytoxin were i.p. injected repeatedly to mice, and the effects on lymphoid tissues were examined. The weight and morphology of the thymus were influenced during exposure but had generally recovered after 1 month of withdrawal. The ratio of lymphocytes to total leukocytes in bloo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Toxicon (Oxford) 1997-05, Vol.35 (5), p.679-688
Hauptverfasser:	Ito, Emiko, Ohkusu, Misako, Terao, Kiyoshi, Yasumoto, Takeshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylamides - administration & dosage Acrylamides - toxicity Animal poisons toxicology. Antivenoms Animals B-lymphocytes Biological and medical sciences Brachyura Cnidarian Venoms - administration & dosage Cnidarian Venoms - toxicity crabs demania alcalai Flow Cytometry Injections, Intraperitoneal intraperitoneal injection isolation leukocytes Lymphocyte Count lymphocytes Lymphoid Tissue - drug effects Lymphoid Tissue - pathology Male Medical sciences Mice Mice, Inbred ICR Organ Size - drug effects ratios spleen Spleen - drug effects Spleen - pathology thymus gland Thymus Gland - drug effects Thymus Gland - pathology toxicity Toxicology toxins
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Sublethal doses of palytoxin were i.p. injected repeatedly to mice, and the effects on lymphoid tissues were examined. The weight and morphology of the thymus were influenced during exposure but had generally recovered after 1 month of withdrawal. The ratio of lymphocytes to total leukocytes in blood was decreased during the injection term, and did not recover to a normal level even after 1 month of withdrawal. The component of B-cells in the lymphocytes was clarified as being responsible for the small number of lymphocytes in the recovery process.
ISSN:	0041-0101 1879-3150
DOI:	10.1016/S0041-0101(96)00184-5