Inflammatory cytokines IFN-gamma plus TNF-alpha induce regulated expression of CD80 (B7-1) but not CD86 (B7-2) on murine fibroblasts

Optimal T cell activation requires signals delivered via both the TCR and the costimulatory receptors. Considerable experimental data now suggest that this costimulatory signal is generated predominantly by CD28 when engaged by its ligands CD80 (B7-1) and/or CD86 (B7-2). Whether T cell activation is...

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Veröffentlicht in:	The Journal of immunology (1950) 1997-05, Vol.158 (10), p.4921-4929
Hauptverfasser:	Pechhold, K, Patterson, NB, Craighead, N, Lee, KP, June, CH, Harlan, DM
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen-Presenting Cells - immunology Antigens, CD - metabolism B7-1 Antigen - metabolism B7-2 Antigen Cells, Cultured Drug Synergism Fibroblasts - immunology Flow Cytometry Gene Expression Interferon-gamma - administration & dosage Lymphocyte Activation Membrane Glycoproteins - metabolism Mice Mice, Inbred C57BL Mice, Transgenic RNA, Messenger - genetics T-Lymphocytes - immunology Tumor Necrosis Factor-alpha - administration & dosage Up-Regulation
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