Inhibition of the Monooxygenase-Dependent Metabolism of Coumarins in Man and Mouse by Azole Analogues of Metyrapone

Metyrapone is known as an inhibitor of cytochrome P450-dependent monooxygenases which are involved in the metabolism of xenobiotics and steroids (endobiotics) in mammals, and in that of ecdysteroids in insects. Recently, derivatives of A-phenyl-B-imidazolyl- and A-phenyl-B-triazolyl-metyrapone were...

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Veröffentlicht in:	Pesticide biochemistry and physiology 1996-09, Vol.56 (1), p.53-61
Hauptverfasser:	Möbus, Eric, Bélai, Iván, Legrum, Wolfgang
Format:	Artikel
Sprache:	eng
Schlagworte:	ACTIVIDAD ENZIMATICA ACTIVITE ENZYMATIQUE Biological and medical sciences Chemical control CITOCROMO P 450 CITOCROMOS Control COUMARINE CUMARINAS CYTOCHROME CYTOCHROME P 450 Diploptera punctata EXPERIMENTACION IN VITRO EXPERIMENTATION IN VITRO FOIE Fundamental and applied biological sciences. Psychology GENERO HUMANO GENRE HUMAIN HIGADO INHIBICION INHIBITION Medical sciences METABOLISME METABOLISMO Musca domestica Neobellieria bullata ORGANITE CELLULAIRE ORGANULOS CITOPLASMICOS Pesticides, fertilizers and other agrochemicals toxicology Phytopathology. Animal pests. Plant and forest protection PIRIDINAS Protozoa. Invertebrates PYRIDINE RATON SOURIS Toxicology
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