Effects of (R)-9-(2-phosphonylmethoxypropyl)adenine monotherapy on chronic SIV infection in macaques

(R)-9-(2-Phosphonylmethoxypropyl)adenine (PMPA) acts as a reverse transcriptase inhibitor of retroviruses and has been shown to be effective against acute simian immunodeficiency virus (SIV) infection in macaques. To study its efficacy at different stages of infection, we tested PMPA in cynomolgus m...

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Veröffentlicht in:	AIDS research and human retroviruses 1997-05, Vol.13 (8), p.707-712
Hauptverfasser:	TSAI, C.-C, FOLLIS, K. E, BECK, T. W, SABO, A, BISCHOFBERGER, N, DAILEY, P. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - therapeutic use Adenine - toxicity Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - pharmacokinetics Antiviral Agents - therapeutic use Biological and medical sciences CD4-Positive T-Lymphocytes - drug effects Drug Evaluation Lymphocyte Count - drug effects Lymphocyte Subsets - cytology Lymphoid Tissue - pathology Lymphoid Tissue - virology Macaca fascicularis Macaca fascicularis - virology Medical sciences Organophosphonates Organophosphorus Compounds - therapeutic use Organophosphorus Compounds - toxicity Pharmacology. Drug treatments Retroviridae Infections - blood Retroviridae Infections - drug therapy simian immunodeficiency virus Simian Immunodeficiency Virus - drug effects Simian Immunodeficiency Virus - genetics Simian Immunodeficiency Virus - growth & development Tenofovir
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