Expression of recombinant human plasminogen in mammalian cells is augmented by suppression of plasmin activity

We present evidence that over-expression of human plasminogen, the precursor to the serine protease plasmin, can be cytotoxic to mammalian cells. When an expression vector containing plasminogen cDNA is transfected into baby hamster kidney cells, the number of drug-resistant colonies as well as the...

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Veröffentlicht in:	The Journal of biological chemistry 1991-08, Vol.266 (23), p.15286-15292
Hauptverfasser:	BUSBY, S. J, MULVIHILL, E, DON RAO, ASHOK KUMAR, A, LIOUBIN, P, HEIPEL, M, SPRECHER, C, PRUNKARD, D, GAMBEE, J, FOSTER, D. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoradiography Base Sequence Biological and medical sciences Biotechnology Cell Survival Cells, Cultured Cricetinae DNA - genetics Fibrinolysin - metabolism Fundamental and applied biological sciences. Psychology Humans Methods. Procedures. Technologies Molecular Sequence Data Mutation Plasmids plasmin Plasminogen - biosynthesis Plasminogen - genetics Precipitin Tests Protein engineering Recombinant Proteins - biosynthesis Recombinant Proteins - genetics RNA, Antisense - genetics Transfection Urokinase-Type Plasminogen Activator - genetics
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