Disulfide Bond Assignment of .omega.-Agatoxins IVB and IVC: Discovery of a D-Serine Residue in .omega.-Agatoxin IVB

A TCEP (tris(2-carboxyethyl)phosphine)-based reduction/cysteine amidoalkylation strategy was utilized to solve the disulfide structures of omega -agatoxins IVB (1) and IVC (2). These p-type calcium channel antagonists, isolated from the American funnel-web spider Agelenopsis aperta, were found to ha...

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Veröffentlicht in:	Journal of the American Chemical Society 1994-11, Vol.116 (23), p.10426-10436
Hauptverfasser:	Heck, Steven D, Kelbaugh, Paul R, Kelly, Mary E, Thadeio, Peter F, Saccomano, Nicholas A, Stroh, Justin G, Volkmann, Robert A
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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