Carcinogen-induced lymphomagenesis in pim-1 transgenic mice : dose dependence and involvement of myc and ras

Transgenic mice overexpressing the pim-1 oncogene in their lymphoid compartments are predisposed to T-cell lymphomagenesis but only to the extent that approximately 10% of the transgenic mice develop lymphomas within 34 weeks after birth. Recently, we have shown that lymphomagenesis in pim-1 transge...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1991-02, Vol.51 (3), p.958-963
Hauptverfasser:	BREUER, M, WIENTJENS, E, VERBEEK, S, SLEBOS, R, BERNS, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Chemical agents Codon DNA Probes Dose-Response Relationship, Drug Ethylnitrosourea Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - genetics Genes, myc Genes, ras Lymphoma, T-Cell - chemically induced Lymphoma, T-Cell - genetics Medical sciences Mice Mice, Transgenic - genetics Molecular Sequence Data Moloney murine leukemia virus Mutation - genetics Tumors
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