In Vitro Interaction between Dirithromycin or Its Metabolite, Erythromycylamine, and Oxidative Polymorphonuclear Metabolism

The direct stimulation by neutrophil-infectious bacteria induces an increase in the production of reactive oxygen species which is an important host defense mechanism. Antibiotics that enter rapidly and are concentrated in neutrophils, can stimulate or damage this function. In this study, an in vitr...

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Veröffentlicht in:	Journal of antibiotics 1997/01/25, Vol.50(1), pp.53-57
Hauptverfasser:	MOUTARD, I., GRESSIER, B., BRUNET, C., DINE, T., LUYCKX, M., CAZIN, M., CAZIN, J. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Erythromycin - analogs & derivatives Erythromycin - pharmacology Humans Macrolides Medical sciences N-Formylmethionine Leucyl-Phenylalanine - pharmacology Neutrophils - drug effects Neutrophils - metabolism Pharmacology. Drug treatments Superoxides - metabolism Tetradecanoylphorbol Acetate - pharmacology
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