Expression and post-translational processing of gastrin in heterologous endocrine cells

The biosynthesis of gastrin involves a complex series of post-translational processing reactions that result in the formation of a biologically active secretory product. To study the mechanisms for two specific reactions in gastrin processing, namely dibasic cleavage and amidation, we infected AtT-2...

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Veröffentlicht in:	The Journal of biological chemistry 1991-04, Vol.266 (10), p.6133-6136
Hauptverfasser:	Marino, L R, Takeuchi, T, Dickinson, C J, Yamada, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoacids, peptides. Hormones. Neuropeptides Analytical, structural and metabolic biochemistry Animals Base Sequence Biological and medical sciences Cell Line Chromatography, Gel Dexamethasone - pharmacology DNA - genetics Endocrine Glands - cytology Endocrine Glands - metabolism Fundamental and applied biological sciences. Psychology Gastrins - biosynthesis Gastrins - genetics Gene Expression Regulation, Viral Genes, Viral Genetic Vectors Humans Mice Molecular Sequence Data Mutation Protein Processing, Post-Translational Proteins Rats Retroviridae - genetics site-directed mutagenesis Transfection Tumor Cells, Cultured
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