Neuroprotective effects of the strychnine-insensitive glycine site NMDA antagonist ( R)-HA-966 in an experimental model of Parkinson's disease

The neuroprotective effects of ( R)-HA-966 and ( S)-HA-966 (3-amino-1-hydroxy-2-pyrrolidinone) were examined in an MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-induced animal model of Parkinson's disease. Systemic pretreatment of C57 black mice with the strychnine-insensitive glycine sit...

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Veröffentlicht in:	Brain research 1997-06, Vol.759 (1), p.1-8
Hauptverfasser:	Kanthasamy, Anumantha G, Kanthasamy, Arthi, Matsumoto, Rae R, Vu, Toan Q, Truong, Daniel D
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology Animals Behavior, Animal - drug effects Brain - drug effects Brain - metabolism Brain - pathology Dopamine Dopamine - metabolism Dopamine Agents - pharmacology Drug Resistance Drug screening Excitatory Amino Acid Agonists - therapeutic use Excitotoxicity Glutamate Glycine Agents - pharmacology Male Mice Mice, Inbred C57BL MPTP N-Methylaspartate - antagonists & inhibitors Neurodegeneration Neurons - drug effects Neurons - pathology Neuroprotective Agents - therapeutic use Parkinson Disease, Secondary - chemically induced Parkinson Disease, Secondary - drug therapy Parkinson Disease, Secondary - psychology Pyrrolidinones - therapeutic use Stereoisomerism Striatum Strychnine - pharmacology Substantia nigra
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