Acute and subacute inhalation toxicity studies of a new broad spectrum insect repellent, N, N-diethylphenylacetamide
N, N-Diethylphenylacetamide (DEPA) is an inexpensive, long-acting and broad spectrum insect repellent. The acute LC 50 for a 4-h exposure of DEPA aerosol was found to be 1.451 mg l −1 (1.290–1.633) in male and 1.375 mg l −1 (1.307–1.447) in female rats. DEPA did not cause delayed deaths. Acute expos...
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| Veröffentlicht in: | Toxicology (Amsterdam) 1991-03, Vol.67 (1), p.85-96 |
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| container_title | Toxicology (Amsterdam) |
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| creator | Vijayaraghavan, R. Rao, S.S. Suryanarayana, M.V.S. Swamy, R.V. |
| description | N,
N-Diethylphenylacetamide (DEPA) is an inexpensive, long-acting and broad spectrum insect repellent. The acute LC
50 for a 4-h exposure of DEPA aerosol was found to be 1.451 mg l
−1 (1.290–1.633) in male and 1.375 mg l
−1 (1.307–1.447) in female rats. DEPA did not cause delayed deaths. Acute exposure to 0.9 LC
50 revealed that liver might be a target organ for DEPA toxicity. On subacute exposures to 0.2, 0.6 and 0.8 LC
50 for 6 h per day, 5 days a week for 2 weeks, there was no significant change in the 0.2 LC
50 group, as evaluated by the body weight gain and organ body weight ratio. The minimal changes observed in the 0.6 LC
50 group were of reversible type as the animals recovered on cessation of exposure. A massive concentration of 0.8 LC
50 produced lethal effects. The study shows that DEPA has a low mammalian toxicity by inhalation as was found earlier with cutaneous application of the insect repellent. |
| doi_str_mv | 10.1016/0300-483X(91)90166-X |
| format | Article |
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N-Diethylphenylacetamide (DEPA) is an inexpensive, long-acting and broad spectrum insect repellent. The acute LC
50 for a 4-h exposure of DEPA aerosol was found to be 1.451 mg l
−1 (1.290–1.633) in male and 1.375 mg l
−1 (1.307–1.447) in female rats. DEPA did not cause delayed deaths. Acute exposure to 0.9 LC
50 revealed that liver might be a target organ for DEPA toxicity. On subacute exposures to 0.2, 0.6 and 0.8 LC
50 for 6 h per day, 5 days a week for 2 weeks, there was no significant change in the 0.2 LC
50 group, as evaluated by the body weight gain and organ body weight ratio. The minimal changes observed in the 0.6 LC
50 group were of reversible type as the animals recovered on cessation of exposure. A massive concentration of 0.8 LC
50 produced lethal effects. The study shows that DEPA has a low mammalian toxicity by inhalation as was found earlier with cutaneous application of the insect repellent.</description><identifier>ISSN: 0300-483X</identifier><identifier>EISSN: 1879-3185</identifier><identifier>DOI: 10.1016/0300-483X(91)90166-X</identifier><identifier>PMID: 2017765</identifier><identifier>CODEN: TXICDD</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Acetamides - administration & dosage ; Acetamides - toxicity ; Acetanilides ; Aerosols ; Animals ; Atmosphere Exposure Chambers ; Biological and medical sciences ; Body Weight - drug effects ; Female ; Inhalation ; Insect repellent ; Insect Repellents - administration & dosage ; Insect Repellents - toxicity ; Male ; Medical sciences ; N, N-diethylphenylacetamide ; Pesticides, fertilizers and other agrochemicals toxicology ; Rats ; Rats, Inbred Strains ; Toxicity ; Toxicology</subject><ispartof>Toxicology (Amsterdam), 1991-03, Vol.67 (1), p.85-96</ispartof><rights>1991</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-8e22b02652e363f9a756726afe3671b8c59722ad54394ee916c9b8bb2e66c7ec3</citedby><cites>FETCH-LOGICAL-c418t-8e22b02652e363f9a756726afe3671b8c59722ad54394ee916c9b8bb2e66c7ec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0300483X9190166X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19626517$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2017765$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vijayaraghavan, R.</creatorcontrib><creatorcontrib>Rao, S.S.</creatorcontrib><creatorcontrib>Suryanarayana, M.V.S.</creatorcontrib><creatorcontrib>Swamy, R.V.</creatorcontrib><title>Acute and subacute inhalation toxicity studies of a new broad spectrum insect repellent, N, N-diethylphenylacetamide</title><title>Toxicology (Amsterdam)</title><addtitle>Toxicology</addtitle><description>N,
N-Diethylphenylacetamide (DEPA) is an inexpensive, long-acting and broad spectrum insect repellent. The acute LC
50 for a 4-h exposure of DEPA aerosol was found to be 1.451 mg l
−1 (1.290–1.633) in male and 1.375 mg l
−1 (1.307–1.447) in female rats. DEPA did not cause delayed deaths. Acute exposure to 0.9 LC
50 revealed that liver might be a target organ for DEPA toxicity. On subacute exposures to 0.2, 0.6 and 0.8 LC
50 for 6 h per day, 5 days a week for 2 weeks, there was no significant change in the 0.2 LC
50 group, as evaluated by the body weight gain and organ body weight ratio. The minimal changes observed in the 0.6 LC
50 group were of reversible type as the animals recovered on cessation of exposure. A massive concentration of 0.8 LC
50 produced lethal effects. The study shows that DEPA has a low mammalian toxicity by inhalation as was found earlier with cutaneous application of the insect repellent.</description><subject>Acetamides - administration & dosage</subject><subject>Acetamides - toxicity</subject><subject>Acetanilides</subject><subject>Aerosols</subject><subject>Animals</subject><subject>Atmosphere Exposure Chambers</subject><subject>Biological and medical sciences</subject><subject>Body Weight - drug effects</subject><subject>Female</subject><subject>Inhalation</subject><subject>Insect repellent</subject><subject>Insect Repellents - administration & dosage</subject><subject>Insect Repellents - toxicity</subject><subject>Male</subject><subject>Medical sciences</subject><subject>N, N-diethylphenylacetamide</subject><subject>Pesticides, fertilizers and other agrochemicals toxicology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Toxicity</subject><subject>Toxicology</subject><issn>0300-483X</issn><issn>1879-3185</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFr3DAQhUVpSLZp_0ELurS0EKeSbEvWpRBC0hRCc2lhb2Isj1kFW3Yluc3--2izS3oLCKTRvPeY-Qh5z9k5Z1x-ZSVjRdWU68-af9H5RxbrV2TFG6WLkjf1a7J6lpyQNzHeM8ZEWcljciwYV0rWK5Iu7JKQgu9oXFp4KpzfwADJTZ6m6cFZl7Y0pqVzGOnUU6Ae_9E2TJA9M9oUljF7Yn7RgDMOA_p0Rn_mU2RP2myHeYN-O4DFBKPr8C056mGI-O5wn5Lf11e_Lm-K27vvPy4vbgtb8SYVDQrRMiFrgaUsew2qlkpI6HOpeNvYWishoKurUleImkur26ZtBUppFdrylHza585h-rNgTGZ00eYBweO0RMNr3bBK6iys9kIbphgD9mYOboSwNZyZHWyzI2l2JI3m5gm2WWfbh0P-0o7YPZsOdHP_46EP0cLQB_DWxf_ZWubluMq6b3sdZhh_HQYTrUNvsXMhUzXd5F4e5BFCSp0J</recordid><startdate>19910325</startdate><enddate>19910325</enddate><creator>Vijayaraghavan, R.</creator><creator>Rao, S.S.</creator><creator>Suryanarayana, M.V.S.</creator><creator>Swamy, R.V.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19910325</creationdate><title>Acute and subacute inhalation toxicity studies of a new broad spectrum insect repellent, N, N-diethylphenylacetamide</title><author>Vijayaraghavan, R. ; Rao, S.S. ; Suryanarayana, M.V.S. ; Swamy, R.V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-8e22b02652e363f9a756726afe3671b8c59722ad54394ee916c9b8bb2e66c7ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Acetamides - administration & dosage</topic><topic>Acetamides - toxicity</topic><topic>Acetanilides</topic><topic>Aerosols</topic><topic>Animals</topic><topic>Atmosphere Exposure Chambers</topic><topic>Biological and medical sciences</topic><topic>Body Weight - drug effects</topic><topic>Female</topic><topic>Inhalation</topic><topic>Insect repellent</topic><topic>Insect Repellents - administration & dosage</topic><topic>Insect Repellents - toxicity</topic><topic>Male</topic><topic>Medical sciences</topic><topic>N, N-diethylphenylacetamide</topic><topic>Pesticides, fertilizers and other agrochemicals toxicology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Toxicity</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vijayaraghavan, R.</creatorcontrib><creatorcontrib>Rao, S.S.</creatorcontrib><creatorcontrib>Suryanarayana, M.V.S.</creatorcontrib><creatorcontrib>Swamy, R.V.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Toxicology (Amsterdam)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vijayaraghavan, R.</au><au>Rao, S.S.</au><au>Suryanarayana, M.V.S.</au><au>Swamy, R.V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute and subacute inhalation toxicity studies of a new broad spectrum insect repellent, N, N-diethylphenylacetamide</atitle><jtitle>Toxicology (Amsterdam)</jtitle><addtitle>Toxicology</addtitle><date>1991-03-25</date><risdate>1991</risdate><volume>67</volume><issue>1</issue><spage>85</spage><epage>96</epage><pages>85-96</pages><issn>0300-483X</issn><eissn>1879-3185</eissn><coden>TXICDD</coden><abstract>N,
N-Diethylphenylacetamide (DEPA) is an inexpensive, long-acting and broad spectrum insect repellent. The acute LC
50 for a 4-h exposure of DEPA aerosol was found to be 1.451 mg l
−1 (1.290–1.633) in male and 1.375 mg l
−1 (1.307–1.447) in female rats. DEPA did not cause delayed deaths. Acute exposure to 0.9 LC
50 revealed that liver might be a target organ for DEPA toxicity. On subacute exposures to 0.2, 0.6 and 0.8 LC
50 for 6 h per day, 5 days a week for 2 weeks, there was no significant change in the 0.2 LC
50 group, as evaluated by the body weight gain and organ body weight ratio. The minimal changes observed in the 0.6 LC
50 group were of reversible type as the animals recovered on cessation of exposure. A massive concentration of 0.8 LC
50 produced lethal effects. The study shows that DEPA has a low mammalian toxicity by inhalation as was found earlier with cutaneous application of the insect repellent.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>2017765</pmid><doi>10.1016/0300-483X(91)90166-X</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-483X |
| ispartof | Toxicology (Amsterdam), 1991-03, Vol.67 (1), p.85-96 |
| issn | 0300-483X 1879-3185 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_15980469 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Acetamides - administration & dosage Acetamides - toxicity Acetanilides Aerosols Animals Atmosphere Exposure Chambers Biological and medical sciences Body Weight - drug effects Female Inhalation Insect repellent Insect Repellents - administration & dosage Insect Repellents - toxicity Male Medical sciences N, N-diethylphenylacetamide Pesticides, fertilizers and other agrochemicals toxicology Rats Rats, Inbred Strains Toxicity Toxicology |
| title | Acute and subacute inhalation toxicity studies of a new broad spectrum insect repellent, N, N-diethylphenylacetamide |
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