Chronic administration of sublethal doses of carbaryl increases pineal N-acetyltransferase and hydroxyindole-O-methyltransferase activities and serum melatonin levels
Attia AM, Reiter RJ, Withyachumnarnkul B, Mostafa MH, Soliman SA, El‐sebae A.‐K.H. Chronic administration of sublethal doses of carbaryl increases pineal N‐acetyltransferase and hydroxy‐0‐ rnethyltransferase activities and serum melatonin levels. J Pineal Res 1 99 1 1 0149‐54. : The purpose of this...
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| creator | Attia, Ahmed M. Reiter, Russel J. Withyachumnarnkul, Boonsirm Mostafa, Mostafa H. Soliman, Salah A. El-sebae, Abdel-Khalek H. |
| description | Attia AM, Reiter RJ, Withyachumnarnkul B, Mostafa MH, Soliman SA, El‐sebae A.‐K.H. Chronic administration of sublethal doses of carbaryl increases pineal N‐acetyltransferase and hydroxy‐0‐ rnethyltransferase activities and serum melatonin levels. J Pineal Res 1 99 1 1 0149‐54.
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The purpose of this study was to examine the effects of chronic administration of sublethal doses of carbaryl on pineal melatonin synthesis. N‐methyl 1‐naphthylcarbamate (carbaryl) (8.33 mg/kg B.W. daily) was administered orally to adult male albino rats for 6 successive days. Nocturnal (0100) N‐acetyltransferase and hydroxyindole‐0‐methyltransferase activities were increased (roughly 75% and 60%, respectively) by carbaryl administration; likewise, carbaryl augmented serum melatonin levels at 2300. Pineal tryptophan, 5‐hydroxytryptophan, serotonin, and 5‐hydroxindole acetic acid levels were unaffected at all three time points. The results indicate that the carbamate pesticide, i.e., carbaryl, modifies pineal melatonin synthesis in vivo. |
| doi_str_mv | 10.1111/j.1600-079X.1991.tb00009.x |
| format | Article |
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The purpose of this study was to examine the effects of chronic administration of sublethal doses of carbaryl on pineal melatonin synthesis. N‐methyl 1‐naphthylcarbamate (carbaryl) (8.33 mg/kg B.W. daily) was administered orally to adult male albino rats for 6 successive days. Nocturnal (0100) N‐acetyltransferase and hydroxyindole‐0‐methyltransferase activities were increased (roughly 75% and 60%, respectively) by carbaryl administration; likewise, carbaryl augmented serum melatonin levels at 2300. Pineal tryptophan, 5‐hydroxytryptophan, serotonin, and 5‐hydroxindole acetic acid levels were unaffected at all three time points. The results indicate that the carbamate pesticide, i.e., carbaryl, modifies pineal melatonin synthesis in vivo.</description><identifier>ISSN: 0742-3098</identifier><identifier>EISSN: 1600-079X</identifier><identifier>DOI: 10.1111/j.1600-079X.1991.tb00009.x</identifier><identifier>PMID: 1711578</identifier><identifier>CODEN: JPRSE9</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>5-Hydroxytryptophan - metabolism ; Acetylserotonin O-Methyltransferase - metabolism ; Administration, Oral ; Animals ; Arylamine N-Acetyltransferase - metabolism ; Biological and medical sciences ; Carbaryl - administration & dosage ; Carbaryl - toxicity ; Hydroxyindoleacetic Acid - metabolism ; in serum and pineal-indoleamine metabolism-carbaryl-pesticide ; Key words: pineal gland-melatonin ; Key words: pineal gland—melatonin, in serum and pineal—indoleamine metabolism—carbaryl—pesticide ; Male ; Medical sciences ; Melatonin - blood ; Pesticides, fertilizers and other agrochemicals toxicology ; Pineal Gland - drug effects ; Pineal Gland - enzymology ; Radioimmunoassay ; Rats ; Serotonin - metabolism ; Statistics as Topic ; Toxicology ; Tryptophan - metabolism</subject><ispartof>Journal of pineal research, 1991-01, Vol.10 (1), p.49-54</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4679-9a023fdb7ebc6f8e9f2362c4e109b469654a049b008c052091e17919b7f76ae53</citedby><cites>FETCH-LOGICAL-c4679-9a023fdb7ebc6f8e9f2362c4e109b469654a049b008c052091e17919b7f76ae53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-079X.1991.tb00009.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-079X.1991.tb00009.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,4024,27923,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19695365$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1711578$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Attia, Ahmed M.</creatorcontrib><creatorcontrib>Reiter, Russel J.</creatorcontrib><creatorcontrib>Withyachumnarnkul, Boonsirm</creatorcontrib><creatorcontrib>Mostafa, Mostafa H.</creatorcontrib><creatorcontrib>Soliman, Salah A.</creatorcontrib><creatorcontrib>El-sebae, Abdel-Khalek H.</creatorcontrib><title>Chronic administration of sublethal doses of carbaryl increases pineal N-acetyltransferase and hydroxyindole-O-methyltransferase activities and serum melatonin levels</title><title>Journal of pineal research</title><addtitle>J Pineal Res</addtitle><description>Attia AM, Reiter RJ, Withyachumnarnkul B, Mostafa MH, Soliman SA, El‐sebae A.‐K.H. Chronic administration of sublethal doses of carbaryl increases pineal N‐acetyltransferase and hydroxy‐0‐ rnethyltransferase activities and serum melatonin levels. J Pineal Res 1 99 1 1 0149‐54.
:
The purpose of this study was to examine the effects of chronic administration of sublethal doses of carbaryl on pineal melatonin synthesis. N‐methyl 1‐naphthylcarbamate (carbaryl) (8.33 mg/kg B.W. daily) was administered orally to adult male albino rats for 6 successive days. Nocturnal (0100) N‐acetyltransferase and hydroxyindole‐0‐methyltransferase activities were increased (roughly 75% and 60%, respectively) by carbaryl administration; likewise, carbaryl augmented serum melatonin levels at 2300. Pineal tryptophan, 5‐hydroxytryptophan, serotonin, and 5‐hydroxindole acetic acid levels were unaffected at all three time points. The results indicate that the carbamate pesticide, i.e., carbaryl, modifies pineal melatonin synthesis in vivo.</description><subject>5-Hydroxytryptophan - metabolism</subject><subject>Acetylserotonin O-Methyltransferase - metabolism</subject><subject>Administration, Oral</subject><subject>Animals</subject><subject>Arylamine N-Acetyltransferase - metabolism</subject><subject>Biological and medical sciences</subject><subject>Carbaryl - administration & dosage</subject><subject>Carbaryl - toxicity</subject><subject>Hydroxyindoleacetic Acid - metabolism</subject><subject>in serum and pineal-indoleamine metabolism-carbaryl-pesticide</subject><subject>Key words: pineal gland-melatonin</subject><subject>Key words: pineal gland—melatonin, in serum and pineal—indoleamine metabolism—carbaryl—pesticide</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Melatonin - blood</subject><subject>Pesticides, fertilizers and other agrochemicals toxicology</subject><subject>Pineal Gland - drug effects</subject><subject>Pineal Gland - enzymology</subject><subject>Radioimmunoassay</subject><subject>Rats</subject><subject>Serotonin - metabolism</subject><subject>Statistics as Topic</subject><subject>Toxicology</subject><subject>Tryptophan - metabolism</subject><issn>0742-3098</issn><issn>1600-079X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkV2L1DAUhoMo67j6E4Qi6F1r0o-kEbyQQWdX9kNYRfEmpOkJkzFNx6Tdnf4hf6cpHXbBO89NIO_znpycF6FXBGck1ttdRijGKWb8R0Y4J9nQ4Fg8OzxCq3vpMVphVuZpgXn9FD0LYReZuq7pCTohjJCK1Sv0Z731vTMqkW1nnAmDl4PpXdLrJIyNhWErbdL2AcJ8paRvpJ9sYpzyIOfbvXEQkatUKhgmG_0uaPBRS6Rrk-3U-v4wGdf2FtLrtIsd_6HUYG7NYGKv2RDAj13SgZVDnMslFm7BhufoiZY2wIvjeYq-ffr4dX2WXlxvztcfLlJVUsZTLnFe6LZh0Ciqa-A6L2iuSiCYNyXltColLnncVq1wlWNOgDBOeMM0oxKq4hS9Wfruff97hDCIzgQF1koH_RgEqTirWMEi-G4Ble9D8KDF3psu7kYQLOaQxE7MSYg5CTGHJI4hiUM0vzy-MjYdtA_WJZWovz7qMihpddyWMuEB45RXBZ2nfb9wd8bC9B8TiM9fzkse_enij7nD4d4v_S9B4ycr8f1qI34Wl8XNJb0Rm-IvIqfDMg</recordid><startdate>199101</startdate><enddate>199101</enddate><creator>Attia, Ahmed M.</creator><creator>Reiter, Russel J.</creator><creator>Withyachumnarnkul, Boonsirm</creator><creator>Mostafa, Mostafa H.</creator><creator>Soliman, Salah A.</creator><creator>El-sebae, Abdel-Khalek H.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>199101</creationdate><title>Chronic administration of sublethal doses of carbaryl increases pineal N-acetyltransferase and hydroxyindole-O-methyltransferase activities and serum melatonin levels</title><author>Attia, Ahmed M. ; Reiter, Russel J. ; Withyachumnarnkul, Boonsirm ; Mostafa, Mostafa H. ; Soliman, Salah A. ; El-sebae, Abdel-Khalek H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4679-9a023fdb7ebc6f8e9f2362c4e109b469654a049b008c052091e17919b7f76ae53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>5-Hydroxytryptophan - metabolism</topic><topic>Acetylserotonin O-Methyltransferase - metabolism</topic><topic>Administration, Oral</topic><topic>Animals</topic><topic>Arylamine N-Acetyltransferase - metabolism</topic><topic>Biological and medical sciences</topic><topic>Carbaryl - administration & dosage</topic><topic>Carbaryl - toxicity</topic><topic>Hydroxyindoleacetic Acid - metabolism</topic><topic>in serum and pineal-indoleamine metabolism-carbaryl-pesticide</topic><topic>Key words: pineal gland-melatonin</topic><topic>Key words: pineal gland—melatonin, in serum and pineal—indoleamine metabolism—carbaryl—pesticide</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Melatonin - blood</topic><topic>Pesticides, fertilizers and other agrochemicals toxicology</topic><topic>Pineal Gland - drug effects</topic><topic>Pineal Gland - enzymology</topic><topic>Radioimmunoassay</topic><topic>Rats</topic><topic>Serotonin - metabolism</topic><topic>Statistics as Topic</topic><topic>Toxicology</topic><topic>Tryptophan - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Attia, Ahmed M.</creatorcontrib><creatorcontrib>Reiter, Russel J.</creatorcontrib><creatorcontrib>Withyachumnarnkul, Boonsirm</creatorcontrib><creatorcontrib>Mostafa, Mostafa H.</creatorcontrib><creatorcontrib>Soliman, Salah A.</creatorcontrib><creatorcontrib>El-sebae, Abdel-Khalek H.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Journal of pineal research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Attia, Ahmed M.</au><au>Reiter, Russel J.</au><au>Withyachumnarnkul, Boonsirm</au><au>Mostafa, Mostafa H.</au><au>Soliman, Salah A.</au><au>El-sebae, Abdel-Khalek H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic administration of sublethal doses of carbaryl increases pineal N-acetyltransferase and hydroxyindole-O-methyltransferase activities and serum melatonin levels</atitle><jtitle>Journal of pineal research</jtitle><addtitle>J Pineal Res</addtitle><date>1991-01</date><risdate>1991</risdate><volume>10</volume><issue>1</issue><spage>49</spage><epage>54</epage><pages>49-54</pages><issn>0742-3098</issn><eissn>1600-079X</eissn><coden>JPRSE9</coden><abstract>Attia AM, Reiter RJ, Withyachumnarnkul B, Mostafa MH, Soliman SA, El‐sebae A.‐K.H. Chronic administration of sublethal doses of carbaryl increases pineal N‐acetyltransferase and hydroxy‐0‐ rnethyltransferase activities and serum melatonin levels. J Pineal Res 1 99 1 1 0149‐54.
:
The purpose of this study was to examine the effects of chronic administration of sublethal doses of carbaryl on pineal melatonin synthesis. N‐methyl 1‐naphthylcarbamate (carbaryl) (8.33 mg/kg B.W. daily) was administered orally to adult male albino rats for 6 successive days. Nocturnal (0100) N‐acetyltransferase and hydroxyindole‐0‐methyltransferase activities were increased (roughly 75% and 60%, respectively) by carbaryl administration; likewise, carbaryl augmented serum melatonin levels at 2300. Pineal tryptophan, 5‐hydroxytryptophan, serotonin, and 5‐hydroxindole acetic acid levels were unaffected at all three time points. The results indicate that the carbamate pesticide, i.e., carbaryl, modifies pineal melatonin synthesis in vivo.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>1711578</pmid><doi>10.1111/j.1600-079X.1991.tb00009.x</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of pineal research, 1991-01, Vol.10 (1), p.49-54 |
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| subjects | 5-Hydroxytryptophan - metabolism Acetylserotonin O-Methyltransferase - metabolism Administration, Oral Animals Arylamine N-Acetyltransferase - metabolism Biological and medical sciences Carbaryl - administration & dosage Carbaryl - toxicity Hydroxyindoleacetic Acid - metabolism in serum and pineal-indoleamine metabolism-carbaryl-pesticide Key words: pineal gland-melatonin Key words: pineal gland—melatonin, in serum and pineal—indoleamine metabolism—carbaryl—pesticide Male Medical sciences Melatonin - blood Pesticides, fertilizers and other agrochemicals toxicology Pineal Gland - drug effects Pineal Gland - enzymology Radioimmunoassay Rats Serotonin - metabolism Statistics as Topic Toxicology Tryptophan - metabolism |
| title | Chronic administration of sublethal doses of carbaryl increases pineal N-acetyltransferase and hydroxyindole-O-methyltransferase activities and serum melatonin levels |
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