Alteration of HIV-1 infectivity and neutralization by a single amino acid replacement in the V3 loop domain

The V3 loop (residues 303-338) of the human immunodeficiency virus type 1 (HIV-1) gp120 envelope protein represents a principal neutralizing determinant for the virus. An HIV-1 proviral clone containing a mutation in the V3 loop was constructed in which the proline residue at position 313 was change...

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Veröffentlicht in:	AIDS research and human retroviruses 1991-07, Vol.7 (7), p.595-603
Hauptverfasser:	IVANOFF, L. A, LOONEY, D. J, MCDANAL, C, MORRIS, J. F, WONG-STAAL, F, LANGLOIS, A. J, PETTEWAY, S. R, MATTHEWS, T. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine - chemistry Amino Acid Sequence Animals Base Sequence Biological and medical sciences Cell Fusion Cell Line, Transformed Cloning, Molecular DNA, Viral Fundamental and applied biological sciences. Psychology HIV Envelope Protein gp120 - chemistry HIV Envelope Protein gp120 - physiology HIV-1 - genetics HIV-1 - immunology HIV-1 - pathogenicity HIV-1 - physiology Humans Microbiology Molecular Sequence Data Mutagenesis, Site-Directed Neutralization Tests Peptide Fragments - chemistry Peptide Fragments - physiology Proline - chemistry Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Virology Virus Replication - genetics
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