Arsenic alters cytosine methylation patterns of the promoter of the tumor suppressor gene p53 in human lung cells: a model for a mechanism of carcinogenesis

Arsenic is a potent human carcinogen to which there is significant worldwide exposure through natural contamination of food and drinking water sources. Because arsenic is detoxified via methylation using a methyltransferase (MTase) and S-adenosylmethionine (SAM) as the methyl donor, we hypothesized...

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Veröffentlicht in:	Mutation Research-Reviews in Mutation Research 1997-06, Vol.386 (3), p.263-277
Hauptverfasser:	Mass, Marc J, Wang, Liangjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - etiology Adenocarcinoma - genetics Arsenic Arsenic - toxicity Base Sequence Carcinogenesis Carcinogens - toxicity Cytosine DNA Methylation Gene Expression Regulation, Neoplastic - drug effects Genes, Tumor Suppressor Humans Lung Neoplasms - etiology Lung Neoplasms - genetics Molecular Sequence Data Promoter Regions, Genetic - genetics Tumor Cells, Cultured Tumor Suppressor Protein p53 - genetics
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