Mutagenicity of 5-aza-2′-Deoxycytidine is Mediated by the Mammalian DNA Methyltransferase

The cytosine analog 5-aza-2′-deoxycytidine has been used clinically to reactivate genes silenced by DNA methylation. In particular, patients with β -thalassemia show fetal globin expression after administration of this hypomethylating drug. In addition, silencing of tumor suppressor gene expression...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1997-04, Vol.94 (9), p.4681-4685
Hauptverfasser:	Jackson-Grusby, Laurie, Laird, Peter W., Magge, Suresh N., Moeller, Benjamin J., Jaenisch, Rudolf
Format:	Artikel
Sprache:	eng
Schlagworte:	Adducts Animals Antimetabolites, Antineoplastic - pharmacology Azacitidine - analogs & derivatives Azacitidine - pharmacology Biological Sciences Chemical bases Chemotherapy Decitabine Deoxyribonucleic acid Dinucleoside Phosphates - genetics DNA DNA Methylation Enzymes Escherichia coli Genetic mutation Genomics Mammals Methylation Methyltransferases - metabolism Mice Mice, Inbred C57BL Mice, Transgenic Models, Chemical Models, Genetic Mutagenesis Mutagens - pharmacology Mutation Transgenes Transgenic animals Tumors
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