Inhibitory activity of xanthone derivatives isolated from some Guttiferaeous plants against DNA topoisomerases I and II

Inhibitory activity of xanthone derivatives isolated from some Guttiferaeous plants against DNA topoisomerases I and II

A xanthone derivative, subelliptenone F, and the related compounds showed an intensive inhibitory effect against topoisomerases I and II in in vitro experiments. These xanthones are prospective lead compounds for anticancer drugs.

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1997, Vol.45 (2), p.418-420
Hauptverfasser: TOSA, H, IINUMA, M, TANAKA, T, NOZAKI, H, IKEDA, S, TSUTSUI, KEN, TSUTSUI, KIMIKO, YAMADA, M, FUJIMORI, S
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Calophyllum inophyllum
Garcinia mangostana
General pharmacology
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
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Zusammenfassung:A xanthone derivative, subelliptenone F, and the related compounds showed an intensive inhibitory effect against topoisomerases I and II in in vitro experiments. These xanthones are prospective lead compounds for anticancer drugs.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.45.418