Expression of myc-family, myc-interacting, and myc-target genes during preimplantation mouse development
Previous studies indicated that members of the myc gene family may be essential for preimplantation development. Other studies revealed that preimplantation embryos lacking c‐myc, N‐myc, or L‐myc are viable, indicating that these genes are either not essential for preimplantation development or can...
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| Veröffentlicht in: | Molecular reproduction and development 1997-05, Vol.47 (1), p.57-65 |
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| creator | Domashenko, Alevtina D. Latham, Keith E. Hatton, Kimi S. |
| description | Previous studies indicated that members of the myc gene family may be essential for preimplantation development. Other studies revealed that preimplantation embryos lacking c‐myc, N‐myc, or L‐myc are viable, indicating that these genes are either not essential for preimplantation development or can be substituted for functionally by other myc gene family members. To investigate the possible role of these genes during preimplantation development, we determined the temporal patterns of expression of four members of the myc gene family, genes encoding myc‐associated proteins, and four putative MYC target genes. We observed a sequential pattern of myc gene expression, with the L‐myc mRNA expressed as a maternal transcript, the c‐myc mRNA expressed during the 4‐cell through morula stages, and the B‐myc mRNA expressed highly at the morula and blastocysts stages. B‐myc was the predominant family member expressed during preimplantation development. The mxi mRNA was not detectable and the mad mRNA was detectable only as a maternal transcript. The max mRNA, however, was expressed both as a maternal mRNA and as an embryonic message throughout most of preimplantation development. Three putative MYC target genes (Odc, cyclin E, and prothymosin‐α) were tarnscriptionally induced during the 2‐cell stage, and their mRNAs increased sharply in abundance during development to the morula and blastocyst stages. Another putative MYC target gene, cyclin A, was expressed both as a maternal mRNA and as an embryonic transcript. These data support the view that the expression of myc target genes may be supported initially through the expression of maternally inherited MYC proteins and corresponding mRNAs and that subsequent stage‐specific changes in expression of myc genes, myc‐associated genes, and myc target genes may control early differentiative events around the time of implantation. Mol. Reprod. Dev. 47:57–65, 1997. © 1997 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/(SICI)1098-2795(199705)47:1<57::AID-MRD8>3.0.CO;2-P |
| format | Article |
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Other studies revealed that preimplantation embryos lacking c‐myc, N‐myc, or L‐myc are viable, indicating that these genes are either not essential for preimplantation development or can be substituted for functionally by other myc gene family members. To investigate the possible role of these genes during preimplantation development, we determined the temporal patterns of expression of four members of the myc gene family, genes encoding myc‐associated proteins, and four putative MYC target genes. We observed a sequential pattern of myc gene expression, with the L‐myc mRNA expressed as a maternal transcript, the c‐myc mRNA expressed during the 4‐cell through morula stages, and the B‐myc mRNA expressed highly at the morula and blastocysts stages. B‐myc was the predominant family member expressed during preimplantation development. The mxi mRNA was not detectable and the mad mRNA was detectable only as a maternal transcript. The max mRNA, however, was expressed both as a maternal mRNA and as an embryonic message throughout most of preimplantation development. Three putative MYC target genes (Odc, cyclin E, and prothymosin‐α) were tarnscriptionally induced during the 2‐cell stage, and their mRNAs increased sharply in abundance during development to the morula and blastocyst stages. Another putative MYC target gene, cyclin A, was expressed both as a maternal mRNA and as an embryonic transcript. These data support the view that the expression of myc target genes may be supported initially through the expression of maternally inherited MYC proteins and corresponding mRNAs and that subsequent stage‐specific changes in expression of myc genes, myc‐associated genes, and myc target genes may control early differentiative events around the time of implantation. Mol. Reprod. Dev. 47:57–65, 1997. © 1997 Wiley‐Liss, Inc.</description><identifier>ISSN: 1040-452X</identifier><identifier>EISSN: 1098-2795</identifier><identifier>DOI: 10.1002/(SICI)1098-2795(199705)47:1<57::AID-MRD8>3.0.CO;2-P</identifier><identifier>PMID: 9110315</identifier><identifier>CODEN: MREDEE</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Amanitins - pharmacology ; Animals ; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors ; Basic-Leucine Zipper Transcription Factors ; Biological and medical sciences ; Blastocyst - metabolism ; cell cycle ; Cell Differentiation ; Chorionic Gonadotropin - pharmacology ; Cyclins - genetics ; DNA-Binding Proteins - genetics ; Embryology: invertebrates and vertebrates. Teratology ; Embryonic and Fetal Development ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation, Developmental ; Genes, myc - genetics ; Male ; Mice ; Mice, Inbred Strains ; Molecular embryology ; Morula - metabolism ; myc ; Oocytes - metabolism ; Ornithine Decarboxylase - genetics ; preimplantation mouse embryo ; Protein Precursors - genetics ; Repressor Proteins ; RNA, Messenger - metabolism ; RT-PCR ; Thymosin - analogs & derivatives ; Thymosin - genetics ; Transcription Factors ; Transcription, Genetic</subject><ispartof>Molecular reproduction and development, 1997-05, Vol.47 (1), p.57-65</ispartof><rights>Copyright © 1997 Wiley‐Liss, Inc.</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291098-2795%28199705%2947%3A1%3C57%3A%3AAID-MRD8%3E3.0.CO%3B2-P$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291098-2795%28199705%2947%3A1%3C57%3A%3AAID-MRD8%3E3.0.CO%3B2-P$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2650746$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9110315$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Domashenko, Alevtina D.</creatorcontrib><creatorcontrib>Latham, Keith E.</creatorcontrib><creatorcontrib>Hatton, Kimi S.</creatorcontrib><title>Expression of myc-family, myc-interacting, and myc-target genes during preimplantation mouse development</title><title>Molecular reproduction and development</title><addtitle>Mol. Reprod. Dev</addtitle><description>Previous studies indicated that members of the myc gene family may be essential for preimplantation development. Other studies revealed that preimplantation embryos lacking c‐myc, N‐myc, or L‐myc are viable, indicating that these genes are either not essential for preimplantation development or can be substituted for functionally by other myc gene family members. To investigate the possible role of these genes during preimplantation development, we determined the temporal patterns of expression of four members of the myc gene family, genes encoding myc‐associated proteins, and four putative MYC target genes. We observed a sequential pattern of myc gene expression, with the L‐myc mRNA expressed as a maternal transcript, the c‐myc mRNA expressed during the 4‐cell through morula stages, and the B‐myc mRNA expressed highly at the morula and blastocysts stages. B‐myc was the predominant family member expressed during preimplantation development. The mxi mRNA was not detectable and the mad mRNA was detectable only as a maternal transcript. The max mRNA, however, was expressed both as a maternal mRNA and as an embryonic message throughout most of preimplantation development. Three putative MYC target genes (Odc, cyclin E, and prothymosin‐α) were tarnscriptionally induced during the 2‐cell stage, and their mRNAs increased sharply in abundance during development to the morula and blastocyst stages. Another putative MYC target gene, cyclin A, was expressed both as a maternal mRNA and as an embryonic transcript. These data support the view that the expression of myc target genes may be supported initially through the expression of maternally inherited MYC proteins and corresponding mRNAs and that subsequent stage‐specific changes in expression of myc genes, myc‐associated genes, and myc target genes may control early differentiative events around the time of implantation. Mol. Reprod. Dev. 47:57–65, 1997. © 1997 Wiley‐Liss, Inc.</description><subject>Amanitins - pharmacology</subject><subject>Animals</subject><subject>Basic Helix-Loop-Helix Leucine Zipper Transcription Factors</subject><subject>Basic-Leucine Zipper Transcription Factors</subject><subject>Biological and medical sciences</subject><subject>Blastocyst - metabolism</subject><subject>cell cycle</subject><subject>Cell Differentiation</subject><subject>Chorionic Gonadotropin - pharmacology</subject><subject>Cyclins - genetics</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Embryonic and Fetal Development</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Genes, myc - genetics</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Molecular embryology</subject><subject>Morula - metabolism</subject><subject>myc</subject><subject>Oocytes - metabolism</subject><subject>Ornithine Decarboxylase - genetics</subject><subject>preimplantation mouse embryo</subject><subject>Protein Precursors - genetics</subject><subject>Repressor Proteins</subject><subject>RNA, Messenger - metabolism</subject><subject>RT-PCR</subject><subject>Thymosin - analogs & derivatives</subject><subject>Thymosin - genetics</subject><subject>Transcription Factors</subject><subject>Transcription, Genetic</subject><issn>1040-452X</issn><issn>1098-2795</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kWtv0zAUhiMEGtvgJyDlA0KbtJRjJ67tDk2asrEVjXWiXPbtyE1OiiE34hTWf4_TVv3ky_vq0bGfIDhnMGIA_P3JfJpOTxloFXGpxQnTWoI4TeSEfRByMrmcXkWfv1ypi3gEo3R2zqOHZ8Hhvv982CcQJYI_vgyOnPsFAForOAgONGMQM3EY_Lx-ajtyzjZ12BRhtc6iwlS2XJ9t9rbuqTNZb-vlWWjqfHPZm25JfbikmlyYrzofhh5iq7Y0dW_6gVU1K0dhTn-pbNqK6v5V8KIwpaPXu_U4-Pbx-mt6G93Nbqbp5V1kYwUqSiAe04JTUYgCDKnEKK4BEskEyEzJIs8512IhhVa5JMgSE0tBUqvMBwsZHwfvtty2a_6syPVYWZdR6UcjPxMyocdjAcIX3-yKq0VFObadrUy3xt3X-PztLjcuM2XRmTqzbl_jHiKTsa_Nt7V_tqT1PmaAg0McFOKgBAcluFWIiUSGQqI3iINBjBEwnSHHh83ZU6Mt1bqenvZU0_3GsfQPxh_3Nyi-f4LbR36P8_g_qNejoA</recordid><startdate>199705</startdate><enddate>199705</enddate><creator>Domashenko, Alevtina D.</creator><creator>Latham, Keith E.</creator><creator>Hatton, Kimi S.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TM</scope></search><sort><creationdate>199705</creationdate><title>Expression of myc-family, myc-interacting, and myc-target genes during preimplantation mouse development</title><author>Domashenko, Alevtina D. ; Latham, Keith E. ; Hatton, Kimi S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i3808-4036eb2eff5f0ae84a82900471507c87fdd2295b7598d7e0c4a375e798cd22b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Amanitins - pharmacology</topic><topic>Animals</topic><topic>Basic Helix-Loop-Helix Leucine Zipper Transcription Factors</topic><topic>Basic-Leucine Zipper Transcription Factors</topic><topic>Biological and medical sciences</topic><topic>Blastocyst - metabolism</topic><topic>cell cycle</topic><topic>Cell Differentiation</topic><topic>Chorionic Gonadotropin - pharmacology</topic><topic>Cyclins - genetics</topic><topic>DNA-Binding Proteins - genetics</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Embryonic and Fetal Development</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Genes, myc - genetics</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Molecular embryology</topic><topic>Morula - metabolism</topic><topic>myc</topic><topic>Oocytes - metabolism</topic><topic>Ornithine Decarboxylase - genetics</topic><topic>preimplantation mouse embryo</topic><topic>Protein Precursors - genetics</topic><topic>Repressor Proteins</topic><topic>RNA, Messenger - metabolism</topic><topic>RT-PCR</topic><topic>Thymosin - analogs & derivatives</topic><topic>Thymosin - genetics</topic><topic>Transcription Factors</topic><topic>Transcription, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Domashenko, Alevtina D.</creatorcontrib><creatorcontrib>Latham, Keith E.</creatorcontrib><creatorcontrib>Hatton, Kimi S.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Nucleic Acids Abstracts</collection><jtitle>Molecular reproduction and development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Domashenko, Alevtina D.</au><au>Latham, Keith E.</au><au>Hatton, Kimi S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of myc-family, myc-interacting, and myc-target genes during preimplantation mouse development</atitle><jtitle>Molecular reproduction and development</jtitle><addtitle>Mol. Reprod. Dev</addtitle><date>1997-05</date><risdate>1997</risdate><volume>47</volume><issue>1</issue><spage>57</spage><epage>65</epage><pages>57-65</pages><issn>1040-452X</issn><eissn>1098-2795</eissn><coden>MREDEE</coden><abstract>Previous studies indicated that members of the myc gene family may be essential for preimplantation development. Other studies revealed that preimplantation embryos lacking c‐myc, N‐myc, or L‐myc are viable, indicating that these genes are either not essential for preimplantation development or can be substituted for functionally by other myc gene family members. To investigate the possible role of these genes during preimplantation development, we determined the temporal patterns of expression of four members of the myc gene family, genes encoding myc‐associated proteins, and four putative MYC target genes. We observed a sequential pattern of myc gene expression, with the L‐myc mRNA expressed as a maternal transcript, the c‐myc mRNA expressed during the 4‐cell through morula stages, and the B‐myc mRNA expressed highly at the morula and blastocysts stages. B‐myc was the predominant family member expressed during preimplantation development. The mxi mRNA was not detectable and the mad mRNA was detectable only as a maternal transcript. The max mRNA, however, was expressed both as a maternal mRNA and as an embryonic message throughout most of preimplantation development. Three putative MYC target genes (Odc, cyclin E, and prothymosin‐α) were tarnscriptionally induced during the 2‐cell stage, and their mRNAs increased sharply in abundance during development to the morula and blastocyst stages. Another putative MYC target gene, cyclin A, was expressed both as a maternal mRNA and as an embryonic transcript. These data support the view that the expression of myc target genes may be supported initially through the expression of maternally inherited MYC proteins and corresponding mRNAs and that subsequent stage‐specific changes in expression of myc genes, myc‐associated genes, and myc target genes may control early differentiative events around the time of implantation. Mol. Reprod. Dev. 47:57–65, 1997. © 1997 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>9110315</pmid><doi>10.1002/(SICI)1098-2795(199705)47:1<57::AID-MRD8>3.0.CO;2-P</doi><tpages>9</tpages></addata></record> |
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| subjects | Amanitins - pharmacology Animals Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Basic-Leucine Zipper Transcription Factors Biological and medical sciences Blastocyst - metabolism cell cycle Cell Differentiation Chorionic Gonadotropin - pharmacology Cyclins - genetics DNA-Binding Proteins - genetics Embryology: invertebrates and vertebrates. Teratology Embryonic and Fetal Development Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental Genes, myc - genetics Male Mice Mice, Inbred Strains Molecular embryology Morula - metabolism myc Oocytes - metabolism Ornithine Decarboxylase - genetics preimplantation mouse embryo Protein Precursors - genetics Repressor Proteins RNA, Messenger - metabolism RT-PCR Thymosin - analogs & derivatives Thymosin - genetics Transcription Factors Transcription, Genetic |
| title | Expression of myc-family, myc-interacting, and myc-target genes during preimplantation mouse development |
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