Structure-function studies on human macrophage colony-stimulating factor (M-CSF)

M‐CSF (CSF‐1) can be produced in a variety of structural forms that may affect function in vivo. Truncated, nonglycosylated forms of recombinant M‐CSF (rM‐CSF) from E. coli have been refolded in vitro in high yield and shown to be functionally equivalent in vitro to glycosylated rM‐CSF secreted from...

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