Antitumor activity of sodium valproate in cultures of human neuroblastoma cells

Valproic acid (VPA) is a simple branched-chain fatty acid that has anticonvulsant activity and is widely used in the treatment of epilepsy. VPA was found to effect growth and differentiation of human neuroblastoma (NB) cells in vitro at concentrations that have been achieved in humans with no signif...

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Veröffentlicht in:	Anti-cancer drugs 1996-09, Vol.7 (7), p.766-773
Hauptverfasser:	Cinatl, Jindrich, Cinatl, Jaroslav, Scholz, Martin, Driever, Pablo Hernáiz, Henrich, Dirk, Kabickova, Hana, Vogel, Jens-U, Doerr, Hans W, Kornhuber, Bernhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Adhesion Molecules - metabolism Cell Differentiation - drug effects Cell Division - drug effects Drug Screening Assays, Antitumor Humans Killer Cells, Lymphokine-Activated - immunology Killer Cells, Natural - immunology Microscopy, Electron Neoplasm Proteins - metabolism Neural Cell Adhesion Molecules - metabolism Neuroblastoma - immunology Neuroblastoma - metabolism Neuroblastoma - pathology Neuroblastoma - ultrastructure Neurons - cytology Neurons - drug effects Proto-Oncogene Proteins c-myc - metabolism Tumor Cells, Cultured - drug effects Valproic Acid - pharmacology
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