Prenylation of oncogenic human PTPCAAX protein tyrosine phosphatases
Many isoprenylated proteins are known to participate in signal transduction, but not all have been identified. Using an in vitro prenylation screen, two human cDNAs (PTPCAAXI and PTPCAAX2) homologous to the rat PRL-1 and human OV-1 protein tyrosine phosphatase genes were identified. PTPCAAXI and PTP...
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| Veröffentlicht in: | Cancer letters 1996-12, Vol.110 (1-2), p.49-55 |
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| container_issue | 1-2 |
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| container_title | Cancer letters |
| container_volume | 110 |
| creator | CATES, C. A MICHAEL, R. L STAYROOK, K. R HARVEY, K. A BURKE, Y. D RANDALL, S. K CROWELL, P. L CROWELL, D. N |
| description | Many isoprenylated proteins are known to participate in signal transduction, but not all have been identified. Using an in vitro prenylation screen, two human cDNAs (PTPCAAXI and PTPCAAX2) homologous to the rat PRL-1 and human OV-1 protein tyrosine phosphatase genes were identified. PTPCAAXI and PTPCAAX2 were farnesylated in vitro by mammalian farnesyl:protein transferase, and epitope-tagged PTPCAAX2 was prenylated in epithelial cells. Overexpression of PTPCAAXI and PTPCAAX2 in epithelial cells caused a transformed phenotype in culture and tumor growth in nude mice. Thus, PTPCAAXI and PTPCAAX2 represent a novel class of isoprenylated, oncogenic protein tyrosine phosphatases. |
| doi_str_mv | 10.1016/s0304-3835(96)04459-x |
| format | Article |
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Thus, PTPCAAXI and PTPCAAX2 represent a novel class of isoprenylated, oncogenic protein tyrosine phosphatases.</description><subject>Biological and medical sciences</subject><subject>Cell physiology</subject><subject>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</subject><subject>Fundamental and applied biological sciences. 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Psychology</topic><topic>Molecular and cellular biology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CATES, C. A</creatorcontrib><creatorcontrib>MICHAEL, R. L</creatorcontrib><creatorcontrib>STAYROOK, K. R</creatorcontrib><creatorcontrib>HARVEY, K. A</creatorcontrib><creatorcontrib>BURKE, Y. D</creatorcontrib><creatorcontrib>RANDALL, S. K</creatorcontrib><creatorcontrib>CROWELL, P. L</creatorcontrib><creatorcontrib>CROWELL, D. N</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CATES, C. A</au><au>MICHAEL, R. L</au><au>STAYROOK, K. R</au><au>HARVEY, K. A</au><au>BURKE, Y. D</au><au>RANDALL, S. K</au><au>CROWELL, P. 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| ispartof | Cancer letters, 1996-12, Vol.110 (1-2), p.49-55 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Fundamental and applied biological sciences. Psychology Molecular and cellular biology |
| title | Prenylation of oncogenic human PTPCAAX protein tyrosine phosphatases |
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