Tolerance to cadmium cytotoxicity is induced by zinc through non-metallothionein mechanisms as well as metallothionein induction in cultured cells
To investigate the relationship between metallothionein induction and zinc-induced tolerance to cadmium cytotoxicity at the cell level, Chang liver cells were pretreated with a wide range of concentrations of zinc sulfate and challenged with toxic levels of cadmium after removal of zinc. It was foun...
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| Veröffentlicht in: | Toxicology (Amsterdam) 1997-03, Vol.118 (2), p.85-92 |
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| creator | Mishima, Atsushi Yamamoto, Chika Fujiwara, Yasuyuki Kaji, Toshiyuki |
| description | To investigate the relationship between metallothionein induction and zinc-induced tolerance to cadmium cytotoxicity at the cell level, Chang liver cells were pretreated with a wide range of concentrations of zinc sulfate and challenged with toxic levels of cadmium after removal of zinc. It was found that zinc-pretreated cells were significantly resistant even when the extracellular level of zinc was low and metallothionein was not induced by the metal. Pretreatment with zinc resulted in a lesser accumulation of cadmium and metallothionein after challenge with cadmium. In porcine kidney LLC-PK
1 cells and bovine aortic smooth muscle cells pretreated with low levels of zinc, the intracellular accumulation of cadmium was significantly less and cadmium-induced decrease in intracellular zinc was significantly prevented without a change of metallothionein content; as the result, the toxic effect of cadmium was significantly diminished. It was therefore concluded that a tolerance to cadmium cytotoxicity is induced by zinc via non-metallothionein mechanisms such as decreasing intracellular cadmium as well as metallothionein induction at the cell level. The non-metallothionein mechanism was postulated to be particularly importatnt when the extracellular concentration of zinc is under the threshold for metallothionein induction. |
| doi_str_mv | 10.1016/S0300-483X(96)03565-2 |
| format | Article |
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1 cells and bovine aortic smooth muscle cells pretreated with low levels of zinc, the intracellular accumulation of cadmium was significantly less and cadmium-induced decrease in intracellular zinc was significantly prevented without a change of metallothionein content; as the result, the toxic effect of cadmium was significantly diminished. It was therefore concluded that a tolerance to cadmium cytotoxicity is induced by zinc via non-metallothionein mechanisms such as decreasing intracellular cadmium as well as metallothionein induction at the cell level. The non-metallothionein mechanism was postulated to be particularly importatnt when the extracellular concentration of zinc is under the threshold for metallothionein induction.</description><identifier>ISSN: 0300-483X</identifier><identifier>EISSN: 1879-3185</identifier><identifier>DOI: 10.1016/S0300-483X(96)03565-2</identifier><identifier>PMID: 9129164</identifier><identifier>CODEN: TXICDD</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Analysis of Variance ; Animals ; Aorta ; Biological and medical sciences ; Cadmium ; Cadmium - toxicity ; Cattle ; Cell ; Cells, Cultured ; Chemical and industrial products toxicology. Toxic occupational diseases ; Cytotoxicity ; Fluorometry ; Humans ; Kidney - cytology ; Kidney - drug effects ; Kidney - metabolism ; L-Lactate Dehydrogenase - metabolism ; Liver - cytology ; Liver - drug effects ; Liver - metabolism ; LLC-PK1 Cells - cytology ; LLC-PK1 Cells - drug effects ; LLC-PK1 Cells - metabolism ; Medical sciences ; Metallothionein ; Metallothionein - biosynthesis ; Metallothionein - metabolism ; Metals and various inorganic compounds ; Muscle, Smooth, Vascular - cytology ; Muscle, Smooth, Vascular - drug effects ; Muscle, Smooth, Vascular - metabolism ; Spectrophotometry, Atomic ; Swine ; Tolerance ; Toxicology ; Zinc ; Zinc Sulfate - pharmacology</subject><ispartof>Toxicology (Amsterdam), 1997-03, Vol.118 (2), p.85-92</ispartof><rights>1997</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c517t-77c5404dd4f4c4bf60e0ee5cd516ab67b875dc22ea1835cc076a88720565b5433</citedby><cites>FETCH-LOGICAL-c517t-77c5404dd4f4c4bf60e0ee5cd516ab67b875dc22ea1835cc076a88720565b5433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0300-483X(96)03565-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2620741$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9129164$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mishima, Atsushi</creatorcontrib><creatorcontrib>Yamamoto, Chika</creatorcontrib><creatorcontrib>Fujiwara, Yasuyuki</creatorcontrib><creatorcontrib>Kaji, Toshiyuki</creatorcontrib><title>Tolerance to cadmium cytotoxicity is induced by zinc through non-metallothionein mechanisms as well as metallothionein induction in cultured cells</title><title>Toxicology (Amsterdam)</title><addtitle>Toxicology</addtitle><description>To investigate the relationship between metallothionein induction and zinc-induced tolerance to cadmium cytotoxicity at the cell level, Chang liver cells were pretreated with a wide range of concentrations of zinc sulfate and challenged with toxic levels of cadmium after removal of zinc. It was found that zinc-pretreated cells were significantly resistant even when the extracellular level of zinc was low and metallothionein was not induced by the metal. Pretreatment with zinc resulted in a lesser accumulation of cadmium and metallothionein after challenge with cadmium. In porcine kidney LLC-PK
1 cells and bovine aortic smooth muscle cells pretreated with low levels of zinc, the intracellular accumulation of cadmium was significantly less and cadmium-induced decrease in intracellular zinc was significantly prevented without a change of metallothionein content; as the result, the toxic effect of cadmium was significantly diminished. It was therefore concluded that a tolerance to cadmium cytotoxicity is induced by zinc via non-metallothionein mechanisms such as decreasing intracellular cadmium as well as metallothionein induction at the cell level. The non-metallothionein mechanism was postulated to be particularly importatnt when the extracellular concentration of zinc is under the threshold for metallothionein induction.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Aorta</subject><subject>Biological and medical sciences</subject><subject>Cadmium</subject><subject>Cadmium - toxicity</subject><subject>Cattle</subject><subject>Cell</subject><subject>Cells, Cultured</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Cytotoxicity</subject><subject>Fluorometry</subject><subject>Humans</subject><subject>Kidney - cytology</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>L-Lactate Dehydrogenase - metabolism</subject><subject>Liver - cytology</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>LLC-PK1 Cells - cytology</subject><subject>LLC-PK1 Cells - drug effects</subject><subject>LLC-PK1 Cells - metabolism</subject><subject>Medical sciences</subject><subject>Metallothionein</subject><subject>Metallothionein - biosynthesis</subject><subject>Metallothionein - metabolism</subject><subject>Metals and various inorganic compounds</subject><subject>Muscle, Smooth, Vascular - cytology</subject><subject>Muscle, Smooth, Vascular - drug effects</subject><subject>Muscle, Smooth, Vascular - metabolism</subject><subject>Spectrophotometry, Atomic</subject><subject>Swine</subject><subject>Tolerance</subject><subject>Toxicology</subject><subject>Zinc</subject><subject>Zinc Sulfate - pharmacology</subject><issn>0300-483X</issn><issn>1879-3185</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAQgC0EKkvhESr5gBA9BGzHP8kJoYoCUiUOFImb5YwnrFESl9gBlsfgiXF2V3vg0tPYmm9-NB8hF5y94ozr159ZzVglm_rry1ZfslppVYkHZMMb01Y1b9RDsjkhj8mTlL4zxkQt9Rk5a7louZYb8vc2Dji7CZDmSMH5MSwjhV2OOf4OEPKOhkTD5BdAT7sd_RMmoHk7x-Xblk5xqkbMbhhi3oY4YZjoiLB1U0hjoi7RXzgMa_yf2nfM5VNeFJYhL3PpD4VOT8mj3g0Jnx3jOfly_e726kN18-n9x6u3NxUobnJlDCjJpPeylyC7XjNkiAq84tp12nSNUR6EQMebWgEwo13TGMHKoTol6_qcvDj0vZvjjwVTtmNI6wZuwrgky1WrGtE294NS6lq1poDqAMIcU5qxt3dzGN28s5zZVZrdS7OrEdtqu5dmRam7OA5YuhH9qepoqeSfH_MugRv61VdIJ0xowYzkBXtzwLBc7WfA2SYIWNT6MCNk62O4Z5F_6hW3VA</recordid><startdate>19970328</startdate><enddate>19970328</enddate><creator>Mishima, Atsushi</creator><creator>Yamamoto, Chika</creator><creator>Fujiwara, Yasuyuki</creator><creator>Kaji, Toshiyuki</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7U7</scope></search><sort><creationdate>19970328</creationdate><title>Tolerance to cadmium cytotoxicity is induced by zinc through non-metallothionein mechanisms as well as metallothionein induction in cultured cells</title><author>Mishima, Atsushi ; Yamamoto, Chika ; Fujiwara, Yasuyuki ; Kaji, Toshiyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c517t-77c5404dd4f4c4bf60e0ee5cd516ab67b875dc22ea1835cc076a88720565b5433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Aorta</topic><topic>Biological and medical sciences</topic><topic>Cadmium</topic><topic>Cadmium - toxicity</topic><topic>Cattle</topic><topic>Cell</topic><topic>Cells, Cultured</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Cytotoxicity</topic><topic>Fluorometry</topic><topic>Humans</topic><topic>Kidney - cytology</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>L-Lactate Dehydrogenase - metabolism</topic><topic>Liver - cytology</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>LLC-PK1 Cells - cytology</topic><topic>LLC-PK1 Cells - drug effects</topic><topic>LLC-PK1 Cells - metabolism</topic><topic>Medical sciences</topic><topic>Metallothionein</topic><topic>Metallothionein - biosynthesis</topic><topic>Metallothionein - metabolism</topic><topic>Metals and various inorganic compounds</topic><topic>Muscle, Smooth, Vascular - cytology</topic><topic>Muscle, Smooth, Vascular - drug effects</topic><topic>Muscle, Smooth, Vascular - metabolism</topic><topic>Spectrophotometry, Atomic</topic><topic>Swine</topic><topic>Tolerance</topic><topic>Toxicology</topic><topic>Zinc</topic><topic>Zinc Sulfate - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mishima, Atsushi</creatorcontrib><creatorcontrib>Yamamoto, Chika</creatorcontrib><creatorcontrib>Fujiwara, Yasuyuki</creatorcontrib><creatorcontrib>Kaji, Toshiyuki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Toxicology Abstracts</collection><jtitle>Toxicology (Amsterdam)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mishima, Atsushi</au><au>Yamamoto, Chika</au><au>Fujiwara, Yasuyuki</au><au>Kaji, Toshiyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tolerance to cadmium cytotoxicity is induced by zinc through non-metallothionein mechanisms as well as metallothionein induction in cultured cells</atitle><jtitle>Toxicology (Amsterdam)</jtitle><addtitle>Toxicology</addtitle><date>1997-03-28</date><risdate>1997</risdate><volume>118</volume><issue>2</issue><spage>85</spage><epage>92</epage><pages>85-92</pages><issn>0300-483X</issn><eissn>1879-3185</eissn><coden>TXICDD</coden><abstract>To investigate the relationship between metallothionein induction and zinc-induced tolerance to cadmium cytotoxicity at the cell level, Chang liver cells were pretreated with a wide range of concentrations of zinc sulfate and challenged with toxic levels of cadmium after removal of zinc. It was found that zinc-pretreated cells were significantly resistant even when the extracellular level of zinc was low and metallothionein was not induced by the metal. Pretreatment with zinc resulted in a lesser accumulation of cadmium and metallothionein after challenge with cadmium. In porcine kidney LLC-PK
1 cells and bovine aortic smooth muscle cells pretreated with low levels of zinc, the intracellular accumulation of cadmium was significantly less and cadmium-induced decrease in intracellular zinc was significantly prevented without a change of metallothionein content; as the result, the toxic effect of cadmium was significantly diminished. It was therefore concluded that a tolerance to cadmium cytotoxicity is induced by zinc via non-metallothionein mechanisms such as decreasing intracellular cadmium as well as metallothionein induction at the cell level. The non-metallothionein mechanism was postulated to be particularly importatnt when the extracellular concentration of zinc is under the threshold for metallothionein induction.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>9129164</pmid><doi>10.1016/S0300-483X(96)03565-2</doi><tpages>8</tpages></addata></record> |
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| ispartof | Toxicology (Amsterdam), 1997-03, Vol.118 (2), p.85-92 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Analysis of Variance Animals Aorta Biological and medical sciences Cadmium Cadmium - toxicity Cattle Cell Cells, Cultured Chemical and industrial products toxicology. Toxic occupational diseases Cytotoxicity Fluorometry Humans Kidney - cytology Kidney - drug effects Kidney - metabolism L-Lactate Dehydrogenase - metabolism Liver - cytology Liver - drug effects Liver - metabolism LLC-PK1 Cells - cytology LLC-PK1 Cells - drug effects LLC-PK1 Cells - metabolism Medical sciences Metallothionein Metallothionein - biosynthesis Metallothionein - metabolism Metals and various inorganic compounds Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Spectrophotometry, Atomic Swine Tolerance Toxicology Zinc Zinc Sulfate - pharmacology |
| title | Tolerance to cadmium cytotoxicity is induced by zinc through non-metallothionein mechanisms as well as metallothionein induction in cultured cells |
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