Neurotransmitter markers in the cerebrospinal fluid of normal subjects effects of aging and other confounding factors
We have investigated neurotransmitter-related markers of the cerebrospinal fluid (CSF) in a carefully screened series of normally aging subjects in standardized conditions in order to find out the influence of age and other confounding factors on CSF measures. The levels of 3-methoxy-4-hydroxyglycol...
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| Veröffentlicht in: | Journal of Neural Transmission 1991-01, Vol.84 (1-2), p.103-117 |
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| container_end_page | 117 |
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| container_issue | 1-2 |
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| container_title | Journal of Neural Transmission |
| container_volume | 84 |
| creator | HARTIKAINEN, P SOININEN, H REINIKAINEN, K. J SIRVIOÊ, J SOIKKELI, R RIEKKINEN, P. J |
| description | We have investigated neurotransmitter-related markers of the cerebrospinal fluid (CSF) in a carefully screened series of normally aging subjects in standardized conditions in order to find out the influence of age and other confounding factors on CSF measures. The levels of 3-methoxy-4-hydroxyglycol (MHPG) and the activity of acetylcholinesterase (AChE) also increased with age, while homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5 HIAA) and immunoreactivities of somatostatin (SLI), beta-endorphin (BLI) and adrenocorticotropic hormone (ACTH) were unrelated to age. The gender of subjects had no significant effect on the levels of neurotransmitter markers, while seasonal changes, as well as height and weight of the subjects seemed to cause some variations in the levels of HVA, dopamine-beta-hydroxylase (DBH) and ACTH. The study underscores the importance of standardized conditions and matched patient groups in the CSF studies. |
| doi_str_mv | 10.1007/BF01249114 |
| format | Article |
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J ; SIRVIOÊ, J ; SOIKKELI, R ; RIEKKINEN, P. J</creator><creatorcontrib>HARTIKAINEN, P ; SOININEN, H ; REINIKAINEN, K. J ; SIRVIOÊ, J ; SOIKKELI, R ; RIEKKINEN, P. J</creatorcontrib><description>We have investigated neurotransmitter-related markers of the cerebrospinal fluid (CSF) in a carefully screened series of normally aging subjects in standardized conditions in order to find out the influence of age and other confounding factors on CSF measures. The levels of 3-methoxy-4-hydroxyglycol (MHPG) and the activity of acetylcholinesterase (AChE) also increased with age, while homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5 HIAA) and immunoreactivities of somatostatin (SLI), beta-endorphin (BLI) and adrenocorticotropic hormone (ACTH) were unrelated to age. The gender of subjects had no significant effect on the levels of neurotransmitter markers, while seasonal changes, as well as height and weight of the subjects seemed to cause some variations in the levels of HVA, dopamine-beta-hydroxylase (DBH) and ACTH. The study underscores the importance of standardized conditions and matched patient groups in the CSF studies.</description><identifier>ISSN: 0300-9564</identifier><identifier>EISSN: 1435-1463</identifier><identifier>DOI: 10.1007/BF01249114</identifier><identifier>PMID: 1675857</identifier><identifier>CODEN: JNTMAH</identifier><language>eng</language><publisher>Wien: Springer</publisher><subject>Adrenocorticotropic Hormone - cerebrospinal fluid ; Adult ; Aged ; Aging - cerebrospinal fluid ; Biological and medical sciences ; Biomarkers - cerebrospinal fluid ; Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges ; Cerebrospinal Fluid Proteins - analysis ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Male ; Middle Aged ; Neurotransmitter Agents - cerebrospinal fluid ; Reference Values ; Seasons ; Somatostatin - cerebrospinal fluid ; Vertebrates: nervous system and sense organs</subject><ispartof>Journal of Neural Transmission, 1991-01, Vol.84 (1-2), p.103-117</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-4252a5a935f94ee80bb7e159dae037efb4457df4298ba8137505f5b6754bc67d3</citedby><cites>FETCH-LOGICAL-c353t-4252a5a935f94ee80bb7e159dae037efb4457df4298ba8137505f5b6754bc67d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19661848$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1675857$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HARTIKAINEN, P</creatorcontrib><creatorcontrib>SOININEN, H</creatorcontrib><creatorcontrib>REINIKAINEN, K. J</creatorcontrib><creatorcontrib>SIRVIOÊ, J</creatorcontrib><creatorcontrib>SOIKKELI, R</creatorcontrib><creatorcontrib>RIEKKINEN, P. J</creatorcontrib><title>Neurotransmitter markers in the cerebrospinal fluid of normal subjects effects of aging and other confounding factors</title><title>Journal of Neural Transmission</title><addtitle>J Neural Transm Gen Sect</addtitle><description>We have investigated neurotransmitter-related markers of the cerebrospinal fluid (CSF) in a carefully screened series of normally aging subjects in standardized conditions in order to find out the influence of age and other confounding factors on CSF measures. The levels of 3-methoxy-4-hydroxyglycol (MHPG) and the activity of acetylcholinesterase (AChE) also increased with age, while homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5 HIAA) and immunoreactivities of somatostatin (SLI), beta-endorphin (BLI) and adrenocorticotropic hormone (ACTH) were unrelated to age. The gender of subjects had no significant effect on the levels of neurotransmitter markers, while seasonal changes, as well as height and weight of the subjects seemed to cause some variations in the levels of HVA, dopamine-beta-hydroxylase (DBH) and ACTH. The study underscores the importance of standardized conditions and matched patient groups in the CSF studies.</description><subject>Adrenocorticotropic Hormone - cerebrospinal fluid</subject><subject>Adult</subject><subject>Aged</subject><subject>Aging - cerebrospinal fluid</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - cerebrospinal fluid</subject><subject>Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges</subject><subject>Cerebrospinal Fluid Proteins - analysis</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neurotransmitter Agents - cerebrospinal fluid</subject><subject>Reference Values</subject><subject>Seasons</subject><subject>Somatostatin - cerebrospinal fluid</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0300-9564</issn><issn>1435-1463</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMFPwyAUh4nRzDm9eDfhogeTKhQo7VEXpyaLXvTcAH3MzhYmtAf_e5lbstPL4_fxS96H0CUld5QQef-4IDTnFaX8CE0pZyKjvGDHaEoYIVklCn6KzmJcE0IoleUETWghRSnkFI1vMAY_BOVi3w4DBNyr8A0h4tbh4QuwgQA6-Lhpneqw7ca2wd5i50Of9jjqNZghYrD2f6ZIrVq3wsolLhUEbLyzfnTN9tUqM_gQz9GJVV2Ei_2coc_F08f8JVu-P7_OH5aZYYINGc9FroSqmLAVByiJ1hKoqBoFhEmwmnMhG8vzqtSqpEwKIqzQ6TauTSEbNkM3u95N8D8jxKHu22ig65QDP8Y6dYntpwTe7kCTTo0BbL0JbTLxW1NSbx3XB8cJvtq3jrqH5oDupKb8ep-raFRnk1zTxgNWFQUtecn-AGmIhS8</recordid><startdate>19910101</startdate><enddate>19910101</enddate><creator>HARTIKAINEN, P</creator><creator>SOININEN, H</creator><creator>REINIKAINEN, K. 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J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-4252a5a935f94ee80bb7e159dae037efb4457df4298ba8137505f5b6754bc67d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adrenocorticotropic Hormone - cerebrospinal fluid</topic><topic>Adult</topic><topic>Aged</topic><topic>Aging - cerebrospinal fluid</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - cerebrospinal fluid</topic><topic>Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges</topic><topic>Cerebrospinal Fluid Proteins - analysis</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neurotransmitter Agents - cerebrospinal fluid</topic><topic>Reference Values</topic><topic>Seasons</topic><topic>Somatostatin - cerebrospinal fluid</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HARTIKAINEN, P</creatorcontrib><creatorcontrib>SOININEN, H</creatorcontrib><creatorcontrib>REINIKAINEN, K. J</creatorcontrib><creatorcontrib>SIRVIOÊ, J</creatorcontrib><creatorcontrib>SOIKKELI, R</creatorcontrib><creatorcontrib>RIEKKINEN, P. 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The levels of 3-methoxy-4-hydroxyglycol (MHPG) and the activity of acetylcholinesterase (AChE) also increased with age, while homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5 HIAA) and immunoreactivities of somatostatin (SLI), beta-endorphin (BLI) and adrenocorticotropic hormone (ACTH) were unrelated to age. The gender of subjects had no significant effect on the levels of neurotransmitter markers, while seasonal changes, as well as height and weight of the subjects seemed to cause some variations in the levels of HVA, dopamine-beta-hydroxylase (DBH) and ACTH. The study underscores the importance of standardized conditions and matched patient groups in the CSF studies.</abstract><cop>Wien</cop><cop>New York, NY</cop><pub>Springer</pub><pmid>1675857</pmid><doi>10.1007/BF01249114</doi><tpages>15</tpages></addata></record> |
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| ispartof | Journal of Neural Transmission, 1991-01, Vol.84 (1-2), p.103-117 |
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| subjects | Adrenocorticotropic Hormone - cerebrospinal fluid Adult Aged Aging - cerebrospinal fluid Biological and medical sciences Biomarkers - cerebrospinal fluid Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Cerebrospinal Fluid Proteins - analysis Female Fundamental and applied biological sciences. Psychology Humans Male Middle Aged Neurotransmitter Agents - cerebrospinal fluid Reference Values Seasons Somatostatin - cerebrospinal fluid Vertebrates: nervous system and sense organs |
| title | Neurotransmitter markers in the cerebrospinal fluid of normal subjects effects of aging and other confounding factors |
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