Thiazolidine-diones. Biochemical and biological activity of a novel class of tyrosine protein kinase inhibitors

Various derivatives of thiazolidine-diones have been identified as tyrosine protein kinase inhibitors. The epidermal growth factor (EGF) receptor kinase and c-src kinase were inhibited in vitro with IC50 values in the range of 1-7 microM. The v-abl tyrosine protein kinase was not inhibited by thiazo...

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Veröffentlicht in:	The Journal of biological chemistry 1990-12, Vol.265 (36), p.22255-22261
Hauptverfasser:	Geissler, J F, Traxler, P, Regenass, U, Murray, B J, Roesel, J L, Meyer, T, McGlynn, E, Storni, A, Lydon, N B
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Cell Division - drug effects Cell Line Enzymes and enzyme inhibitors epidermal growth factor ErbB Receptors - drug effects ErbB Receptors - metabolism Fundamental and applied biological sciences. Psychology Humans Hydrolases Indicators and Reagents Kinetics Protein Kinase Inhibitors Protein-Tyrosine Kinases - antagonists & inhibitors Src protein Structure-Activity Relationship Substrate Specificity Thiazoles - chemical synthesis Thiazoles - pharmacology v-Abl protein
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