GABA accelerates excitotoxic cell death in cortical cultures: protection by blockers of GABA-gated chloride channels

The effects of γ-aminobutyric acid (GABA) and related agonists and antagonists on the excitatory cell death were examined in disperesed primary cultures of the rat cerebral cortex. The cytotoxic effects evoked by kainic acid, quisqualic acid andN-methyl- D-aspartic acid were evaluated by phase contr...

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Veröffentlicht in:	Brain research 1991-03, Vol.542 (2), p.254-258
Hauptverfasser:	Erdo¨, Sa´ndor L., Michler, Angelika, Wolff, Joachim R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry and metabolism Biological and medical sciences Cell Survival - drug effects Cells, Cultured Central nervous system Cerebral Cortex - cytology Chloride channel Chloride Channels Chlorides - metabolism Excitotoxicity Fundamental and applied biological sciences. Psychology gamma-Aminobutyric Acid - pharmacology Glutamate Ion Channel Gating Kainate Kainic Acid - pharmacology Membrane Proteins - antagonists & inhibitors N-Methylaspartate - pharmacology Neurotoxins - pharmacology Quisqualic Acid - pharmacology Rat cerebral cortex Rats Vertebrates: nervous system and sense organs
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