Peptide Agonist of the Thrombopoietin Receptor as Potent as the Natural Cytokine

Two families of small peptides that bind to the human thrombopoietin receptor and compete with the binding of the natural ligand thrombopoietin (TPO) were identified from recombinant peptide libraries. The sequences of these peptides were not found in the primary sequence of TPO. Screening libraries...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1997-06, Vol.276 (5319), p.1696-1699
Hauptverfasser:	Cwirla, Steven E., Balasubramanian, Palaniappan, Duffin, David J., Wagstrom, Christopher R., Gates, Christian M., Singer, Sara C., Davis, Ann M., Tansik, Robert L., Mattheakis, Larry C., Boytos, Chris M., Schatz, Peter J., Baccanari, David P., Wrighton, Nicholas C., Barrett, Ronald W., Dower, William J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Analytical, structural and metabolic biochemistry Animals Bacteriophages Binding, Competitive Biological and medical sciences Blood platelets Blood Platelets - cytology Bone marrow Cell Division Cell Line Cells, Cultured Consensus Sequence COS cells Dimerization Dimers Erythropoietin - pharmacology Family (Sociological Unit) Fundamental and applied biological sciences. Psychology Hematopoiesis - drug effects Humans Inhibitory concentration 50 Libraries Medical research Megakaryocytes Megakaryocytes - cytology Mice Molecular Sequence Data Neoplasm Proteins Oligopeptides - metabolism Oligopeptides - pharmacology Peptide Library Peptides Peptides - metabolism Peptides - pharmacology Physiological aspects Platelet Count Protein hormones. Growth factors. Cytokines Proteins Proto-Oncogene Proteins - agonists Proto-Oncogene Proteins - metabolism Receptors Receptors, Cytokine Receptors, Thrombopoietin Recombinant Proteins - metabolism Recombinant Proteins - pharmacology Rodents Thrombopoietin - metabolism Thrombopoietin - pharmacology Transfection
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